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USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor responsible for mounting an anti-oxidation gene expression program to counter oxidative stress. Under unstressed conditions, Kelch-like ECH-associated protein 1 (KEAP1), an adaptor protein for CUL3 E3 ubiquitin ligase, medi...

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Detalles Bibliográficos
Autores principales:	Cai, Changzhou, Ma, Huailu, Peng, Jin, Shen, Xiang, Zhen, Xinghua, Yu, Chaohui, Zhang, Pumin, Ji, Feng, Wang, Jiewei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282087/ https://www.ncbi.nlm.nih.gov/pubmed/37339955 http://dx.doi.org/10.1038/s41467-023-39412-6

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