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Structural basis of α(1A)-adrenergic receptor activation and recognition by an extracellular nanobody

The α(1A-)adrenergic receptor (α(1A)AR) belongs to the family of G protein-coupled receptors that respond to adrenaline and noradrenaline. α(1A)AR is involved in smooth muscle contraction and cognitive function. Here, we present three cryo-electron microscopy structures of human α(1A)AR bound to the...

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Detalles Bibliográficos
Autores principales:	Toyoda, Yosuke, Zhu, Angqi, Kong, Fang, Shan, Sisi, Zhao, Jiawei, Wang, Nan, Sun, Xiaoou, Zhang, Linqi, Yan, Chuangye, Kobilka, Brian K., Liu, Xiangyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282093/ https://www.ncbi.nlm.nih.gov/pubmed/37339967 http://dx.doi.org/10.1038/s41467-023-39310-x

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