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Bryostatin-1: a promising compound for neurological disorders

The central nervous system (CNS) is the most complex system in human body, and there is often a lack of effective treatment strategies for the disorders related with CNS. Natural compounds with multiple pharmacological activities may offer better options because they have broad cellular targets and...

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Autores principales: Tian, Zhen, Lu, Xin-Tong, Jiang, Xun, Tian, Jiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282138/
https://www.ncbi.nlm.nih.gov/pubmed/37351510
http://dx.doi.org/10.3389/fphar.2023.1187411
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author Tian, Zhen
Lu, Xin-Tong
Jiang, Xun
Tian, Jiao
author_facet Tian, Zhen
Lu, Xin-Tong
Jiang, Xun
Tian, Jiao
author_sort Tian, Zhen
collection PubMed
description The central nervous system (CNS) is the most complex system in human body, and there is often a lack of effective treatment strategies for the disorders related with CNS. Natural compounds with multiple pharmacological activities may offer better options because they have broad cellular targets and potentially produce synergic and integrative effects. Bryostatin-1 is one of such promising compounds, a macrolide separated from marine invertebrates. Bryostatin-1 has been shown to produce various biological activities through binding with protein kinase C (PKC). In this review, we mainly summarize the pharmacological effects of bryostatin-1 in the treatment of multiple neurological diseases in preclinical studies and clinical trials. Bryostatin-1 is shown to have great therapeutic potential for Alzheimer’s disease, multiple sclerosis, fragile X syndrome, stroke, traumatic brain injury, and depression. It exhibits significant rescuing effects on the deficits of spatial learning, cognitive function, memory and other neurological functions caused by diseases, producing good neuroprotective effects. The promising neuropharmacological activities of bryostatin-1 suggest that it is a potential candidate for the treatment of related neurological disorders although there are still some issues needed to be addressed before its application in clinic.
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spelling pubmed-102821382023-06-22 Bryostatin-1: a promising compound for neurological disorders Tian, Zhen Lu, Xin-Tong Jiang, Xun Tian, Jiao Front Pharmacol Pharmacology The central nervous system (CNS) is the most complex system in human body, and there is often a lack of effective treatment strategies for the disorders related with CNS. Natural compounds with multiple pharmacological activities may offer better options because they have broad cellular targets and potentially produce synergic and integrative effects. Bryostatin-1 is one of such promising compounds, a macrolide separated from marine invertebrates. Bryostatin-1 has been shown to produce various biological activities through binding with protein kinase C (PKC). In this review, we mainly summarize the pharmacological effects of bryostatin-1 in the treatment of multiple neurological diseases in preclinical studies and clinical trials. Bryostatin-1 is shown to have great therapeutic potential for Alzheimer’s disease, multiple sclerosis, fragile X syndrome, stroke, traumatic brain injury, and depression. It exhibits significant rescuing effects on the deficits of spatial learning, cognitive function, memory and other neurological functions caused by diseases, producing good neuroprotective effects. The promising neuropharmacological activities of bryostatin-1 suggest that it is a potential candidate for the treatment of related neurological disorders although there are still some issues needed to be addressed before its application in clinic. Frontiers Media S.A. 2023-06-07 /pmc/articles/PMC10282138/ /pubmed/37351510 http://dx.doi.org/10.3389/fphar.2023.1187411 Text en Copyright © 2023 Tian, Lu, Jiang and Tian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Tian, Zhen
Lu, Xin-Tong
Jiang, Xun
Tian, Jiao
Bryostatin-1: a promising compound for neurological disorders
title Bryostatin-1: a promising compound for neurological disorders
title_full Bryostatin-1: a promising compound for neurological disorders
title_fullStr Bryostatin-1: a promising compound for neurological disorders
title_full_unstemmed Bryostatin-1: a promising compound for neurological disorders
title_short Bryostatin-1: a promising compound for neurological disorders
title_sort bryostatin-1: a promising compound for neurological disorders
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282138/
https://www.ncbi.nlm.nih.gov/pubmed/37351510
http://dx.doi.org/10.3389/fphar.2023.1187411
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