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Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation

Postoperative cognitive dysfunction (POCD) is a common postsurgical complication in elderly individuals, significantly impacting the quality of life of patients; however, there is currently no effective clinical treatment for POCD. Recent studies have shown that Icariin (ICA) has antiaging effects a...

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Autores principales: Wang, Lifeng, Peng, Guanfa, Chen, Li, Guo, Mingling, Wang, Bingyu, Zhang, Yunmeng, Zhou, Jianshun, Zhong, Maolin, Ye, Junming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282654/
https://www.ncbi.nlm.nih.gov/pubmed/37351155
http://dx.doi.org/10.3389/fnbeh.2023.1162009
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author Wang, Lifeng
Peng, Guanfa
Chen, Li
Guo, Mingling
Wang, Bingyu
Zhang, Yunmeng
Zhou, Jianshun
Zhong, Maolin
Ye, Junming
author_facet Wang, Lifeng
Peng, Guanfa
Chen, Li
Guo, Mingling
Wang, Bingyu
Zhang, Yunmeng
Zhou, Jianshun
Zhong, Maolin
Ye, Junming
author_sort Wang, Lifeng
collection PubMed
description Postoperative cognitive dysfunction (POCD) is a common postsurgical complication in elderly individuals, significantly impacting the quality of life of patients; however, there is currently no effective clinical treatment for POCD. Recent studies have shown that Icariin (ICA) has antiaging effects and improves cognitive function, but its effect in POCD has not been studied. In this study, we investigated the influence of ICA on cognitive function and the TLR4/NF-κB signaling pathway in a POCD rat model. We found that ICA reduced surgery-induced memory impairment, decreased hippocampal inflammatory responses, ameliorated neuronal injury in the hippocampus and inhibited microglial activation. In addition, we also observed that ICA inhibited activation of the TLR4/NF-κB signaling pathway. In summary, our research suggest that ICA can ameliorate surgery-induced memory impairment and that the improvements resulting from administration of ICA may be associated with inhibition of hippocampal neuroinflammation. Our research findings also provide insight into potential therapeutic targets and methods for POCD.
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spelling pubmed-102826542023-06-22 Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation Wang, Lifeng Peng, Guanfa Chen, Li Guo, Mingling Wang, Bingyu Zhang, Yunmeng Zhou, Jianshun Zhong, Maolin Ye, Junming Front Behav Neurosci Behavioral Neuroscience Postoperative cognitive dysfunction (POCD) is a common postsurgical complication in elderly individuals, significantly impacting the quality of life of patients; however, there is currently no effective clinical treatment for POCD. Recent studies have shown that Icariin (ICA) has antiaging effects and improves cognitive function, but its effect in POCD has not been studied. In this study, we investigated the influence of ICA on cognitive function and the TLR4/NF-κB signaling pathway in a POCD rat model. We found that ICA reduced surgery-induced memory impairment, decreased hippocampal inflammatory responses, ameliorated neuronal injury in the hippocampus and inhibited microglial activation. In addition, we also observed that ICA inhibited activation of the TLR4/NF-κB signaling pathway. In summary, our research suggest that ICA can ameliorate surgery-induced memory impairment and that the improvements resulting from administration of ICA may be associated with inhibition of hippocampal neuroinflammation. Our research findings also provide insight into potential therapeutic targets and methods for POCD. Frontiers Media S.A. 2023-06-07 /pmc/articles/PMC10282654/ /pubmed/37351155 http://dx.doi.org/10.3389/fnbeh.2023.1162009 Text en Copyright © 2023 Wang, Peng, Chen, Guo, Wang, Zhang, Zhou, Zhong and Ye. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
Wang, Lifeng
Peng, Guanfa
Chen, Li
Guo, Mingling
Wang, Bingyu
Zhang, Yunmeng
Zhou, Jianshun
Zhong, Maolin
Ye, Junming
Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation
title Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation
title_full Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation
title_fullStr Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation
title_full_unstemmed Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation
title_short Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation
title_sort icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282654/
https://www.ncbi.nlm.nih.gov/pubmed/37351155
http://dx.doi.org/10.3389/fnbeh.2023.1162009
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