The Wiskott–Aldrich syndrome protein is required for positive selection during T-cell lineage differentiation

The Wiskott–Aldrich syndrome (WAS) is an X-linked primary immune deficiency caused by a mutation in the WAS gene. This leads to altered or absent WAS protein (WASp) expression and function resulting in thrombocytopenia, eczema, recurrent infections, and autoimmunity. In T cells, WASp is required for...

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Detalles Bibliográficos
Autores principales: Pille, Melissa, Avila, John, Sanchez, Guillem Sanchez, Goetgeluk, Glenn, De Munter, Stijn, Jansen, Hanne, Billiet, Lore, Weening, Karin, Xue, Haipeng, Bonte, Sarah, Ingels, Joline, De Cock, Laurenz, Pascal, Eva, Deseins, Lucas, Kerre, Tessa, Taghon, Tom, Leclercq, Georges, Vermijlen, David, Davis, Brian, Vandekerckhove, Bart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282776/
https://www.ncbi.nlm.nih.gov/pubmed/37350958
http://dx.doi.org/10.3389/fimmu.2023.1188099

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