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Role of hypoxia inducible factor HIF-1α in heart valves
The 2016 Albert Lasker Basic Medical Research Award and subsequently the 2019 Nobel Prize in Physiology or Medicine were awarded to William Kaelin, Jr., Sir Peter Ratcliffe, and Gregg Semenza for their work on how cells sense and adapt to hypoxic conditions. Their work showed that the changes in gen...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Magdi Yacoub Heart Foundation
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282783/ https://www.ncbi.nlm.nih.gov/pubmed/37351095 http://dx.doi.org/10.21542/gcsp.2023.9 |
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author | Georgy, Mark Salhiyyah, Kareem Yacoub, Magdi H. Chester, Adrian H. |
author_facet | Georgy, Mark Salhiyyah, Kareem Yacoub, Magdi H. Chester, Adrian H. |
author_sort | Georgy, Mark |
collection | PubMed |
description | The 2016 Albert Lasker Basic Medical Research Award and subsequently the 2019 Nobel Prize in Physiology or Medicine were awarded to William Kaelin, Jr., Sir Peter Ratcliffe, and Gregg Semenza for their work on how cells sense and adapt to hypoxic conditions. Their work showed that the changes in gene expression, cell metabolism, and tissue remodelling that occur in response to low oxygen concentrations are orchestrated by the transcription factor, hypoxia inducible factor-1α (HIF-1α). While the effects mediated by HIF-1α have been widely studied, its role in heart valves has only recently been investigated. These studies have shown that HIF-1α expression is evident in mechanisms that regulate the structure and function of heart valves. These include embryonic development, the regulation of the extracellular matrix, angiogenesis and the initiation of the calcification process. This review provides a background on the role and function of HIF-1α in response to hypoxia and a discussion of the available evidence of its involvement in the regulation of heart valves in health and disease. |
format | Online Article Text |
id | pubmed-10282783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Magdi Yacoub Heart Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-102827832023-06-22 Role of hypoxia inducible factor HIF-1α in heart valves Georgy, Mark Salhiyyah, Kareem Yacoub, Magdi H. Chester, Adrian H. Glob Cardiol Sci Pract Review Article The 2016 Albert Lasker Basic Medical Research Award and subsequently the 2019 Nobel Prize in Physiology or Medicine were awarded to William Kaelin, Jr., Sir Peter Ratcliffe, and Gregg Semenza for their work on how cells sense and adapt to hypoxic conditions. Their work showed that the changes in gene expression, cell metabolism, and tissue remodelling that occur in response to low oxygen concentrations are orchestrated by the transcription factor, hypoxia inducible factor-1α (HIF-1α). While the effects mediated by HIF-1α have been widely studied, its role in heart valves has only recently been investigated. These studies have shown that HIF-1α expression is evident in mechanisms that regulate the structure and function of heart valves. These include embryonic development, the regulation of the extracellular matrix, angiogenesis and the initiation of the calcification process. This review provides a background on the role and function of HIF-1α in response to hypoxia and a discussion of the available evidence of its involvement in the regulation of heart valves in health and disease. Magdi Yacoub Heart Foundation 2023-05-11 /pmc/articles/PMC10282783/ /pubmed/37351095 http://dx.doi.org/10.21542/gcsp.2023.9 Text en Copyright ©2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Georgy, Mark Salhiyyah, Kareem Yacoub, Magdi H. Chester, Adrian H. Role of hypoxia inducible factor HIF-1α in heart valves |
title | Role of hypoxia inducible factor HIF-1α in heart valves |
title_full | Role of hypoxia inducible factor HIF-1α in heart valves |
title_fullStr | Role of hypoxia inducible factor HIF-1α in heart valves |
title_full_unstemmed | Role of hypoxia inducible factor HIF-1α in heart valves |
title_short | Role of hypoxia inducible factor HIF-1α in heart valves |
title_sort | role of hypoxia inducible factor hif-1α in heart valves |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282783/ https://www.ncbi.nlm.nih.gov/pubmed/37351095 http://dx.doi.org/10.21542/gcsp.2023.9 |
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