Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A

The APOBEC3 (APOBEC3A-H) enzyme family as a part of the human innate immune system deaminates cytosine to uracil in single-stranded DNA (ssDNA) and thereby prevents the spread of pathogenic genetic information. However, APOBEC3-induced mutagenesis promotes viral and cancer evolution, thus enabling t...

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Detalles Bibliográficos
Autores principales: Kurup, Harikrishnan M., Kvach, Maksim V., Harjes, Stefan, Jameson, Geoffrey B., Harjes, Elena, Filichev, Vyacheslav V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282898/
https://www.ncbi.nlm.nih.gov/pubmed/37282621
http://dx.doi.org/10.1039/d3ob00392b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282898/
https://www.ncbi.nlm.nih.gov/pubmed/37282621
http://dx.doi.org/10.1039/d3ob00392b

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