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Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.)

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) as a zootechnical feed additive (functional group: digestibility enhancers) for all poultry. In a p...

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Autores principales: Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Durjava, Mojca, Dusemund, Birgit, Kouba, Maryline, López‐Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Ortuño Casanova, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282916/
https://www.ncbi.nlm.nih.gov/pubmed/37350850
http://dx.doi.org/10.2903/j.efsa.2023.8047
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author Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Durjava, Mojca
Dusemund, Birgit
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Ortuño Casanova, Jordi
author_facet Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Durjava, Mojca
Dusemund, Birgit
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Ortuño Casanova, Jordi
collection PubMed
description Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) as a zootechnical feed additive (functional group: digestibility enhancers) for all poultry. In a previous opinion, the FEEDAP Panel concluded that Xygest™ HT is safe for all poultry, consumers, and the environment. The additive is not considered to be irritant to eyes and skin but a dermal and a respiratory sensitiser, although exposure by inhalation is unlikely. The Panel also concluded that the additive has the potential to be efficacious in laying hens at 45,000 U/kg complete feed and this conclusion was extrapolated to all laying poultry. However, the Panel could not conclude on the efficacy of the product in growing poultry at the proposed conditions of use. In the current application, the applicant provided an additional efficacy trial in chickens for fattening. The results showed a higher apparent metabolisable energy (nitrogen corrected) in chickens fed the additive at the minimum proposed level of 30,000 U/kg complete feed when compared to the control group. Considering the previously submitted studies in laying hens and chickens for fattening, and the newly submitted study in chickens for fattening, the Panel concluded that Xygest™ HT has the potential to be efficacious to enhance digestibility in all poultry at the corresponding proposed minimum levels in feed.
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spelling pubmed-102829162023-06-22 Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.) Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Durjava, Mojca Dusemund, Birgit Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Ortuño Casanova, Jordi EFSA J Scientific Opinion Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) as a zootechnical feed additive (functional group: digestibility enhancers) for all poultry. In a previous opinion, the FEEDAP Panel concluded that Xygest™ HT is safe for all poultry, consumers, and the environment. The additive is not considered to be irritant to eyes and skin but a dermal and a respiratory sensitiser, although exposure by inhalation is unlikely. The Panel also concluded that the additive has the potential to be efficacious in laying hens at 45,000 U/kg complete feed and this conclusion was extrapolated to all laying poultry. However, the Panel could not conclude on the efficacy of the product in growing poultry at the proposed conditions of use. In the current application, the applicant provided an additional efficacy trial in chickens for fattening. The results showed a higher apparent metabolisable energy (nitrogen corrected) in chickens fed the additive at the minimum proposed level of 30,000 U/kg complete feed when compared to the control group. Considering the previously submitted studies in laying hens and chickens for fattening, and the newly submitted study in chickens for fattening, the Panel concluded that Xygest™ HT has the potential to be efficacious to enhance digestibility in all poultry at the corresponding proposed minimum levels in feed. John Wiley and Sons Inc. 2023-06-21 /pmc/articles/PMC10282916/ /pubmed/37350850 http://dx.doi.org/10.2903/j.efsa.2023.8047 Text en © 2023 European Food Safety Authority. EFSA Journal published by Wiley‐VCH GmbH on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Durjava, Mojca
Dusemund, Birgit
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Ortuño Casanova, Jordi
Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.)
title Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.)
title_full Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.)
title_fullStr Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.)
title_full_unstemmed Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.)
title_short Efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by Komagataella phaffii ATCC PTA‐127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.)
title_sort efficacy of a feed additive consisting of endo‐1,4‐beta‐xylanase produced by komagataella phaffii atcc pta‐127053 (xygest™ ht) for all poultry species (kemin europa n.v.)
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282916/
https://www.ncbi.nlm.nih.gov/pubmed/37350850
http://dx.doi.org/10.2903/j.efsa.2023.8047
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