Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report

Mutations in the complement factor I (CFI) gene have previously been identified as causes of recurrent CNS inflammation. We present a case of a 26-year-old man with 18 episodes of recurrent meningitis, who had a variant in CFI(c.859G>A,p.Gly287Arg) not previously associated with neurologic manife...

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Autores principales: Rolfes, Mary, Harroud, Adil, Zorn, Kelsey C., Tubati, Asritha, Omura, Charles, Kurtz, Kenneth, Matloubian, Mehrdad, Berger, Amy, Chiu, Charles Y., Wilson, Michael R., Ramachandran, Prashanth S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Diagnostic & Treatment Challenges
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282980/
https://www.ncbi.nlm.nih.gov/pubmed/37339889
http://dx.doi.org/10.1212/NXI.0000000000200121
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author Rolfes, Mary
Harroud, Adil
Zorn, Kelsey C.
Tubati, Asritha
Omura, Charles
Kurtz, Kenneth
Matloubian, Mehrdad
Berger, Amy
Chiu, Charles Y.
Wilson, Michael R.
Ramachandran, Prashanth S.
author_facet Rolfes, Mary
Harroud, Adil
Zorn, Kelsey C.
Tubati, Asritha
Omura, Charles
Kurtz, Kenneth
Matloubian, Mehrdad
Berger, Amy
Chiu, Charles Y.
Wilson, Michael R.
Ramachandran, Prashanth S.
author_sort Rolfes, Mary
collection PubMed
description Mutations in the complement factor I (CFI) gene have previously been identified as causes of recurrent CNS inflammation. We present a case of a 26-year-old man with 18 episodes of recurrent meningitis, who had a variant in CFI(c.859G>A,p.Gly287Arg) not previously associated with neurologic manifestations. He achieved remission with canakinumab, a human monoclonal antibody targeted at interleukin-1 beta.
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spelling pubmed-102829802023-06-22 Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report Rolfes, Mary Harroud, Adil Zorn, Kelsey C. Tubati, Asritha Omura, Charles Kurtz, Kenneth Matloubian, Mehrdad Berger, Amy Chiu, Charles Y. Wilson, Michael R. Ramachandran, Prashanth S. Neurol Neuroimmunol Neuroinflamm Diagnostic & Treatment Challenges Mutations in the complement factor I (CFI) gene have previously been identified as causes of recurrent CNS inflammation. We present a case of a 26-year-old man with 18 episodes of recurrent meningitis, who had a variant in CFI(c.859G>A,p.Gly287Arg) not previously associated with neurologic manifestations. He achieved remission with canakinumab, a human monoclonal antibody targeted at interleukin-1 beta. Lippincott Williams & Wilkins 2023-06-20 /pmc/articles/PMC10282980/ /pubmed/37339889 http://dx.doi.org/10.1212/NXI.0000000000200121 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Diagnostic & Treatment Challenges
Rolfes, Mary
Harroud, Adil
Zorn, Kelsey C.
Tubati, Asritha
Omura, Charles
Kurtz, Kenneth
Matloubian, Mehrdad
Berger, Amy
Chiu, Charles Y.
Wilson, Michael R.
Ramachandran, Prashanth S.
Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report
title Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report
title_full Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report
title_fullStr Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report
title_full_unstemmed Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report
title_short Complement Factor I Gene Variant as a Treatable Cause of Recurrent Aseptic Neutrophilic Meningitis: A Case Report
title_sort complement factor i gene variant as a treatable cause of recurrent aseptic neutrophilic meningitis: a case report
topic Diagnostic & Treatment Challenges
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282980/
https://www.ncbi.nlm.nih.gov/pubmed/37339889
http://dx.doi.org/10.1212/NXI.0000000000200121
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