Epigenetic modification in Parkinson’s disease

Parkinson’s disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modificat...

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Autores principales: Song, Hao, Chen, Juanli, Huang, Jin, Sun, Peng, Liu, Yanming, Xu, Li, Wei, Chuanfei, Mu, Xin, Lu, Xianjie, Wang, Wei, Zhang, Nan, Shang, Miwei, Mo, Mei, Zhang, Wei, Zhao, Hui, Han, Fabin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283008/
https://www.ncbi.nlm.nih.gov/pubmed/37351278
http://dx.doi.org/10.3389/fcell.2023.1123621
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author Song, Hao
Chen, Juanli
Huang, Jin
Sun, Peng
Liu, Yanming
Xu, Li
Wei, Chuanfei
Mu, Xin
Lu, Xianjie
Wang, Wei
Zhang, Nan
Shang, Miwei
Mo, Mei
Zhang, Wei
Zhao, Hui
Han, Fabin
author_facet Song, Hao
Chen, Juanli
Huang, Jin
Sun, Peng
Liu, Yanming
Xu, Li
Wei, Chuanfei
Mu, Xin
Lu, Xianjie
Wang, Wei
Zhang, Nan
Shang, Miwei
Mo, Mei
Zhang, Wei
Zhao, Hui
Han, Fabin
author_sort Song, Hao
collection PubMed
description Parkinson’s disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD. In this review, we discuss current understanding of the epigenetic mechanisms that regulate gene expression and neural degeneration and then highlight emerging epigenetic targets and diagnostic and therapeutic biomarkers for treating or preventing PD.
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spelling pubmed-102830082023-06-22 Epigenetic modification in Parkinson’s disease Song, Hao Chen, Juanli Huang, Jin Sun, Peng Liu, Yanming Xu, Li Wei, Chuanfei Mu, Xin Lu, Xianjie Wang, Wei Zhang, Nan Shang, Miwei Mo, Mei Zhang, Wei Zhao, Hui Han, Fabin Front Cell Dev Biol Cell and Developmental Biology Parkinson’s disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD. In this review, we discuss current understanding of the epigenetic mechanisms that regulate gene expression and neural degeneration and then highlight emerging epigenetic targets and diagnostic and therapeutic biomarkers for treating or preventing PD. Frontiers Media S.A. 2023-06-07 /pmc/articles/PMC10283008/ /pubmed/37351278 http://dx.doi.org/10.3389/fcell.2023.1123621 Text en Copyright © 2023 Song, Chen, Huang, Sun, Liu, Xu, Wei, Mu, Lu, Wang, Zhang, Shang, Mo, Zhang, Zhao and Han. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Song, Hao
Chen, Juanli
Huang, Jin
Sun, Peng
Liu, Yanming
Xu, Li
Wei, Chuanfei
Mu, Xin
Lu, Xianjie
Wang, Wei
Zhang, Nan
Shang, Miwei
Mo, Mei
Zhang, Wei
Zhao, Hui
Han, Fabin
Epigenetic modification in Parkinson’s disease
title Epigenetic modification in Parkinson’s disease
title_full Epigenetic modification in Parkinson’s disease
title_fullStr Epigenetic modification in Parkinson’s disease
title_full_unstemmed Epigenetic modification in Parkinson’s disease
title_short Epigenetic modification in Parkinson’s disease
title_sort epigenetic modification in parkinson’s disease
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283008/
https://www.ncbi.nlm.nih.gov/pubmed/37351278
http://dx.doi.org/10.3389/fcell.2023.1123621
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