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An Adverse Outcome Pathway Network for Chemically Induced Oxidative Stress Leading to (Non)genotoxic Carcinogenesis

[Image: see text] Nongenotoxic (NGTX) carcinogens induce cancer via other mechanisms than direct DNA damage. A recognized mode of action for NGTX carcinogens is induction of oxidative stress, a state in which the amount of oxidants in a cell exceeds its antioxidant capacity, leading to regenerative...

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Detalles Bibliográficos
Autores principales: Veltman, Christina H. J., Pennings, Jeroen L. A., van de Water, Bob, Luijten, Mirjam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283045/
https://www.ncbi.nlm.nih.gov/pubmed/37156502
http://dx.doi.org/10.1021/acs.chemrestox.2c00396