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Targeting macrophage Syk enhances responses to immune checkpoint blockade and radiotherapy in high-risk neuroblastoma

BACKGROUND: Neuroblastoma (NB) is considered an immunologically cold tumor and is usually less responsive to immune checkpoint blockade (ICB). Tumor-associated macrophages (TAMs) are highly infiltrated in NB tumors and promote immune escape and resistance to ICB. Hence therapeutic strategies targeti...

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Detalles Bibliográficos
Autores principales:	Rohila, Deepak, Park, In Hwan, Pham, Timothy V., Jones, Riley, Tapia, Elisabette, Liu, Kevin X., Tamayo, Pablo, Yu, Alice, Sharabi, Andrew B., Joshi, Shweta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283071/ https://www.ncbi.nlm.nih.gov/pubmed/37350973 http://dx.doi.org/10.3389/fimmu.2023.1148317

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