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The association between serum albumin and depressive symptoms: a cross-sectional study of NHANES data during 2005–2018
AIMS: The association between serum albumin and depressive symptoms has been unclear in previous epidemiological studies. We explored whether serum albumin is associated with depressive symptoms based on the National Health and Nutrition Examination Survey (NHANES) data. METHODS: This cross-sectiona...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283330/ https://www.ncbi.nlm.nih.gov/pubmed/37340352 http://dx.doi.org/10.1186/s12888-023-04935-1 |
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author | Zhang, Guimei Li, Shuna Wang, Sisi Deng, Fangyi Sun, Xizhe Pan, Jiyang |
author_facet | Zhang, Guimei Li, Shuna Wang, Sisi Deng, Fangyi Sun, Xizhe Pan, Jiyang |
author_sort | Zhang, Guimei |
collection | PubMed |
description | AIMS: The association between serum albumin and depressive symptoms has been unclear in previous epidemiological studies. We explored whether serum albumin is associated with depressive symptoms based on the National Health and Nutrition Examination Survey (NHANES) data. METHODS: This cross-sectional study included 13,681 participants aged ≥ 20 years from the NHANES performed during 2005–2018, which produced nationally representative database. Depressive symptoms were assessed using the Patient Health Questionnaire-9. Serum albumin concentration was measured using the bromocresol purple dye method, and participants were divided into quartiles of serum albumin concentrations. Weighted data were calculated according to analytical guidelines. Logistics regression and linear regression models were used to assess and quantify the association between serum albumin and depressive symptoms. Univariate and stratified analyses were also performed. RESULTS: There were 1551 (10.23%) adults (aged ≥ 20 years) with depressive symptoms among the 13,681. A negative association was found between serum albumin concentration and depressive symptoms. Compared with the lowest albumin quartile, the multivariate-adjusted effect size (95% confidence interval) for depressive symptoms of the fully adjusted model in the highest albumin quartile was 0.77 (0.60 to 0.99) and − 0.38 (− 0.66 to − 0.09) using logistics regression and linear regression models respectively. Current smoking status modified the association between serum albumin concentration and PHQ-9 scores (p for interaction = 0.033). CONCLUSION: This cross-sectional study revealed that albumin concentration is significantly more likely to be a protective factor for depressive symptoms, with the association being more pronounced in non-smokers. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-023-04935-1. |
format | Online Article Text |
id | pubmed-10283330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-102833302023-06-22 The association between serum albumin and depressive symptoms: a cross-sectional study of NHANES data during 2005–2018 Zhang, Guimei Li, Shuna Wang, Sisi Deng, Fangyi Sun, Xizhe Pan, Jiyang BMC Psychiatry Research AIMS: The association between serum albumin and depressive symptoms has been unclear in previous epidemiological studies. We explored whether serum albumin is associated with depressive symptoms based on the National Health and Nutrition Examination Survey (NHANES) data. METHODS: This cross-sectional study included 13,681 participants aged ≥ 20 years from the NHANES performed during 2005–2018, which produced nationally representative database. Depressive symptoms were assessed using the Patient Health Questionnaire-9. Serum albumin concentration was measured using the bromocresol purple dye method, and participants were divided into quartiles of serum albumin concentrations. Weighted data were calculated according to analytical guidelines. Logistics regression and linear regression models were used to assess and quantify the association between serum albumin and depressive symptoms. Univariate and stratified analyses were also performed. RESULTS: There were 1551 (10.23%) adults (aged ≥ 20 years) with depressive symptoms among the 13,681. A negative association was found between serum albumin concentration and depressive symptoms. Compared with the lowest albumin quartile, the multivariate-adjusted effect size (95% confidence interval) for depressive symptoms of the fully adjusted model in the highest albumin quartile was 0.77 (0.60 to 0.99) and − 0.38 (− 0.66 to − 0.09) using logistics regression and linear regression models respectively. Current smoking status modified the association between serum albumin concentration and PHQ-9 scores (p for interaction = 0.033). CONCLUSION: This cross-sectional study revealed that albumin concentration is significantly more likely to be a protective factor for depressive symptoms, with the association being more pronounced in non-smokers. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12888-023-04935-1. BioMed Central 2023-06-20 /pmc/articles/PMC10283330/ /pubmed/37340352 http://dx.doi.org/10.1186/s12888-023-04935-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Zhang, Guimei Li, Shuna Wang, Sisi Deng, Fangyi Sun, Xizhe Pan, Jiyang The association between serum albumin and depressive symptoms: a cross-sectional study of NHANES data during 2005–2018 |
title | The association between serum albumin and depressive symptoms: a cross-sectional study of NHANES data during 2005–2018 |
title_full | The association between serum albumin and depressive symptoms: a cross-sectional study of NHANES data during 2005–2018 |
title_fullStr | The association between serum albumin and depressive symptoms: a cross-sectional study of NHANES data during 2005–2018 |
title_full_unstemmed | The association between serum albumin and depressive symptoms: a cross-sectional study of NHANES data during 2005–2018 |
title_short | The association between serum albumin and depressive symptoms: a cross-sectional study of NHANES data during 2005–2018 |
title_sort | association between serum albumin and depressive symptoms: a cross-sectional study of nhanes data during 2005–2018 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283330/ https://www.ncbi.nlm.nih.gov/pubmed/37340352 http://dx.doi.org/10.1186/s12888-023-04935-1 |
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