DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease

DBI/ACBP (diazepam binding inhibitor, acyl-CoA binding protein) is a phylogenetically conserved paracrine inhibitor of macroautophagy/autophagy. As such, DBI/ACBP acts as a pro-aging molecule. Indeed, we observed that the knockout of ACB1 (the yeast equivalent of human DBI/ACBP) induces autophagy an...

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Detalles Bibliográficos
Autores principales: Montégut, Léa, Joseph, Adrien, Chen, Hui, Abdellatif, Mahmoud, Ruckenstuhl, Christoph, Martins, Isabelle, Madeo, Frank, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Autophagic Punctum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283417/
https://www.ncbi.nlm.nih.gov/pubmed/36579946
http://dx.doi.org/10.1080/15548627.2022.2160565

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