Efficient production of bispecific antibody by FAST-Ig(TM) and its application to NXT007 for the treatment of hemophilia A

Efficient production of bispecific antibodies (BsAbs) in single mammalian cells is essential for basic research and industrial manufacturing. However, preventing unwanted pairing of heavy chains (HCs) and light chains (LCs) is a challenging task. To address this, we created an engineering technology...

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Detalles Bibliográficos
Autores principales: Koga, Hikaru, Yamano, Takashi, Betancur, Juan, Nagatomo, Satoko, Ikeda, Yousuke, Yamaguchi, Kazuki, Nabuchi, Yoshiaki, Sato, Kazuki, Teranishi-Ikawa, Yuri, Sato, Motohiko, Hirayama, Hiroyuki, Hayasaka, Akira, Torizawa, Takuya, Haraya, Kenta, Sampei, Zenjiro, Shiraiwa, Hirotake, Kitazawa, Takehisa, Igawa, Tomoyuki, Kuramochi, Taichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283433/
https://www.ncbi.nlm.nih.gov/pubmed/37339067
http://dx.doi.org/10.1080/19420862.2023.2222441

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