In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022

A difficult-to-control outbreak of Candida auris is ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases of C. auris carriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified...

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Detalles Bibliográficos
Autores principales: Codda, Giulia, Willison, Edward, Magnasco, Laura, Morici, Paola, Giacobbe, Daniele Roberto, Mencacci, Antonella, Marini, Daniele, Mikulska, Malgorzata, Bassetti, Matteo, Marchese, Anna, Di Pilato, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283462/
https://www.ncbi.nlm.nih.gov/pubmed/37022211
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.14.2300161
Descripción
Sumario:A difficult-to-control outbreak of Candida auris is ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases of C. auris carriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified putative cases that no longer occurred as part of one defined outbreak and the emergence of echinocandin (pandrug) resistance following independent selection of FKS1(S639F) and FKS1(F635Y) mutants upon prolonged exposure to caspofungin and/or anidulafungin.

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