In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022

A difficult-to-control outbreak of Candida auris is ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases of C. auris carriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified...

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Autores principales: Codda, Giulia, Willison, Edward, Magnasco, Laura, Morici, Paola, Giacobbe, Daniele Roberto, Mencacci, Antonella, Marini, Daniele, Mikulska, Malgorzata, Bassetti, Matteo, Marchese, Anna, Di Pilato, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283462/
https://www.ncbi.nlm.nih.gov/pubmed/37022211
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.14.2300161
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author Codda, Giulia
Willison, Edward
Magnasco, Laura
Morici, Paola
Giacobbe, Daniele Roberto
Mencacci, Antonella
Marini, Daniele
Mikulska, Malgorzata
Bassetti, Matteo
Marchese, Anna
Di Pilato, Vincenzo
author_facet Codda, Giulia
Willison, Edward
Magnasco, Laura
Morici, Paola
Giacobbe, Daniele Roberto
Mencacci, Antonella
Marini, Daniele
Mikulska, Malgorzata
Bassetti, Matteo
Marchese, Anna
Di Pilato, Vincenzo
author_sort Codda, Giulia
collection PubMed
description A difficult-to-control outbreak of Candida auris is ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases of C. auris carriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified putative cases that no longer occurred as part of one defined outbreak and the emergence of echinocandin (pandrug) resistance following independent selection of FKS1(S639F) and FKS1(F635Y) mutants upon prolonged exposure to caspofungin and/or anidulafungin.
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spelling pubmed-102834622023-06-22 In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022 Codda, Giulia Willison, Edward Magnasco, Laura Morici, Paola Giacobbe, Daniele Roberto Mencacci, Antonella Marini, Daniele Mikulska, Malgorzata Bassetti, Matteo Marchese, Anna Di Pilato, Vincenzo Euro Surveill Rapid Communication A difficult-to-control outbreak of Candida auris is ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases of C. auris carriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified putative cases that no longer occurred as part of one defined outbreak and the emergence of echinocandin (pandrug) resistance following independent selection of FKS1(S639F) and FKS1(F635Y) mutants upon prolonged exposure to caspofungin and/or anidulafungin. European Centre for Disease Prevention and Control (ECDC) 2023-04-06 /pmc/articles/PMC10283462/ /pubmed/37022211 http://dx.doi.org/10.2807/1560-7917.ES.2023.28.14.2300161 Text en This article is copyright of the authors or their affiliated institutions, 2023. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Codda, Giulia
Willison, Edward
Magnasco, Laura
Morici, Paola
Giacobbe, Daniele Roberto
Mencacci, Antonella
Marini, Daniele
Mikulska, Malgorzata
Bassetti, Matteo
Marchese, Anna
Di Pilato, Vincenzo
In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022
title In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022
title_full In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022
title_fullStr In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022
title_full_unstemmed In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022
title_short In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022
title_sort in vivo evolution to echinocandin resistance and increasing clonal heterogeneity in candida auris during a difficult-to-control hospital outbreak, italy, 2019 to 2022
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283462/
https://www.ncbi.nlm.nih.gov/pubmed/37022211
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.14.2300161
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