Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021

A hypervirulent Klebsiella pneumoniae SL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containing bla(NDM-1) and a pla...

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Autores principales: Nielsen, Karen Leth, Sørensen, Marc, Hertz, Frederik Boëtius, Misiakou, Maria Anna, Hasman, Henrik, Häussler, Susanne, Helleberg, Marie, Schønning, Kristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2023
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283472/
https://www.ncbi.nlm.nih.gov/pubmed/37103784
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.17.2300196
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author Nielsen, Karen Leth
Sørensen, Marc
Hertz, Frederik Boëtius
Misiakou, Maria Anna
Hasman, Henrik
Häussler, Susanne
Helleberg, Marie
Schønning, Kristian
author_facet Nielsen, Karen Leth
Sørensen, Marc
Hertz, Frederik Boëtius
Misiakou, Maria Anna
Hasman, Henrik
Häussler, Susanne
Helleberg, Marie
Schønning, Kristian
author_sort Nielsen, Karen Leth
collection PubMed
description A hypervirulent Klebsiella pneumoniae SL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containing bla(NDM-1) and a plasmid containing bla(OXA-48) (pOXA-48); the latter plasmid was horizontally transferred within-patient to Serratia marcescens. The convergence of drug resistance and virulence factors in single plasmids and in different lineages of K. pneumoniae is concerning and requires surveillance.
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spelling pubmed-102834722023-06-22 Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021 Nielsen, Karen Leth Sørensen, Marc Hertz, Frederik Boëtius Misiakou, Maria Anna Hasman, Henrik Häussler, Susanne Helleberg, Marie Schønning, Kristian Euro Surveill Rapid Communication A hypervirulent Klebsiella pneumoniae SL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containing bla(NDM-1) and a plasmid containing bla(OXA-48) (pOXA-48); the latter plasmid was horizontally transferred within-patient to Serratia marcescens. The convergence of drug resistance and virulence factors in single plasmids and in different lineages of K. pneumoniae is concerning and requires surveillance. European Centre for Disease Prevention and Control (ECDC) 2023-04-27 /pmc/articles/PMC10283472/ /pubmed/37103784 http://dx.doi.org/10.2807/1560-7917.ES.2023.28.17.2300196 Text en This article is copyright of the authors or their affiliated institutions, 2023. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Nielsen, Karen Leth
Sørensen, Marc
Hertz, Frederik Boëtius
Misiakou, Maria Anna
Hasman, Henrik
Häussler, Susanne
Helleberg, Marie
Schønning, Kristian
Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021
title Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021
title_full Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021
title_fullStr Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021
title_full_unstemmed Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021
title_short Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021
title_sort within-patient horizontal transfer of poxa-48 from a hypervirulent klebsiella pneumoniae sl218 to serratia marcescens following spread of the k. pneumoniae isolate among hospitalised patients, denmark, 2021
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283472/
https://www.ncbi.nlm.nih.gov/pubmed/37103784
http://dx.doi.org/10.2807/1560-7917.ES.2023.28.17.2300196
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