CVM-1118 (foslinanib), a 2-phenyl-4-quinolone derivative, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1

CVM-1118 (foslinanib) is a phosphoric ester compound selected from 2-phenyl-4-quinolone derivatives. The NCI 60 cancer panel screening showed CVM-1125, the major active metabolite of CVM-1118, to exhibit growth inhibitory and cytotoxic effects at nanomolar range. CVM-1118 possesses multiple bioactiv...

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Detalles Bibliográficos
Autores principales: Shen, Lifen, Chen, Yen-Ling, Huang, Chu-Chun, Shyu, Yu-Chiau, Seftor, Richard E. B., Seftor, Elisabeth A., Hendrix, Mary J. C., Chien, Du-Shieng, Chu, Yi-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pathology and Oncology Archive
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10283505/
https://www.ncbi.nlm.nih.gov/pubmed/37351538
http://dx.doi.org/10.3389/pore.2023.1611038

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