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Fear memory recall involves hippocampal somatostatin interneurons
Fear-related memory traces are encoded by sparse populations of hippocampal principal neurons that are recruited based on their inhibitory–excitatory balance during memory formation. Later, the reactivation of the same principal neurons can recall the memory. The details of this mechanism are still...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284381/ https://www.ncbi.nlm.nih.gov/pubmed/37289847 http://dx.doi.org/10.1371/journal.pbio.3002154 |
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author | Zichó, Krisztián Sos, Katalin E. Papp, Péter Barth, Albert M. Misák, Erik Orosz, Áron Mayer, Márton I. Sebestény, Réka Z. Nyiri, Gábor |
author_facet | Zichó, Krisztián Sos, Katalin E. Papp, Péter Barth, Albert M. Misák, Erik Orosz, Áron Mayer, Márton I. Sebestény, Réka Z. Nyiri, Gábor |
author_sort | Zichó, Krisztián |
collection | PubMed |
description | Fear-related memory traces are encoded by sparse populations of hippocampal principal neurons that are recruited based on their inhibitory–excitatory balance during memory formation. Later, the reactivation of the same principal neurons can recall the memory. The details of this mechanism are still unclear. Here, we investigated whether disinhibition could play a major role in this process. Using optogenetic behavioral experiments, we found that when fear was associated with the inhibition of mouse hippocampal somatostatin positive interneurons, the re-inhibition of the same interneurons could recall fear memory. Pontine nucleus incertus neurons selectively inhibit hippocampal somatostatin cells. We also found that when fear was associated with the activity of these incertus neurons or fibers, the reactivation of the same incertus neurons or fibers could also recall fear memory. These incertus neurons showed correlated activity with hippocampal principal neurons during memory recall and were strongly innervated by memory-related neocortical centers, from which the inputs could also control hippocampal disinhibition in vivo. Nonselective inhibition of these mouse hippocampal somatostatin or incertus neurons impaired memory recall. Our data suggest a novel disinhibition-based memory mechanism in the hippocampus that is supported by local somatostatin interneurons and their pontine brainstem inputs. |
format | Online Article Text |
id | pubmed-10284381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-102843812023-06-22 Fear memory recall involves hippocampal somatostatin interneurons Zichó, Krisztián Sos, Katalin E. Papp, Péter Barth, Albert M. Misák, Erik Orosz, Áron Mayer, Márton I. Sebestény, Réka Z. Nyiri, Gábor PLoS Biol Research Article Fear-related memory traces are encoded by sparse populations of hippocampal principal neurons that are recruited based on their inhibitory–excitatory balance during memory formation. Later, the reactivation of the same principal neurons can recall the memory. The details of this mechanism are still unclear. Here, we investigated whether disinhibition could play a major role in this process. Using optogenetic behavioral experiments, we found that when fear was associated with the inhibition of mouse hippocampal somatostatin positive interneurons, the re-inhibition of the same interneurons could recall fear memory. Pontine nucleus incertus neurons selectively inhibit hippocampal somatostatin cells. We also found that when fear was associated with the activity of these incertus neurons or fibers, the reactivation of the same incertus neurons or fibers could also recall fear memory. These incertus neurons showed correlated activity with hippocampal principal neurons during memory recall and were strongly innervated by memory-related neocortical centers, from which the inputs could also control hippocampal disinhibition in vivo. Nonselective inhibition of these mouse hippocampal somatostatin or incertus neurons impaired memory recall. Our data suggest a novel disinhibition-based memory mechanism in the hippocampus that is supported by local somatostatin interneurons and their pontine brainstem inputs. Public Library of Science 2023-06-08 /pmc/articles/PMC10284381/ /pubmed/37289847 http://dx.doi.org/10.1371/journal.pbio.3002154 Text en © 2023 Zichó et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zichó, Krisztián Sos, Katalin E. Papp, Péter Barth, Albert M. Misák, Erik Orosz, Áron Mayer, Márton I. Sebestény, Réka Z. Nyiri, Gábor Fear memory recall involves hippocampal somatostatin interneurons |
title | Fear memory recall involves hippocampal somatostatin interneurons |
title_full | Fear memory recall involves hippocampal somatostatin interneurons |
title_fullStr | Fear memory recall involves hippocampal somatostatin interneurons |
title_full_unstemmed | Fear memory recall involves hippocampal somatostatin interneurons |
title_short | Fear memory recall involves hippocampal somatostatin interneurons |
title_sort | fear memory recall involves hippocampal somatostatin interneurons |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284381/ https://www.ncbi.nlm.nih.gov/pubmed/37289847 http://dx.doi.org/10.1371/journal.pbio.3002154 |
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