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Fear memory recall involves hippocampal somatostatin interneurons

Fear-related memory traces are encoded by sparse populations of hippocampal principal neurons that are recruited based on their inhibitory–excitatory balance during memory formation. Later, the reactivation of the same principal neurons can recall the memory. The details of this mechanism are still...

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Autores principales: Zichó, Krisztián, Sos, Katalin E., Papp, Péter, Barth, Albert M., Misák, Erik, Orosz, Áron, Mayer, Márton I., Sebestény, Réka Z., Nyiri, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284381/
https://www.ncbi.nlm.nih.gov/pubmed/37289847
http://dx.doi.org/10.1371/journal.pbio.3002154
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author Zichó, Krisztián
Sos, Katalin E.
Papp, Péter
Barth, Albert M.
Misák, Erik
Orosz, Áron
Mayer, Márton I.
Sebestény, Réka Z.
Nyiri, Gábor
author_facet Zichó, Krisztián
Sos, Katalin E.
Papp, Péter
Barth, Albert M.
Misák, Erik
Orosz, Áron
Mayer, Márton I.
Sebestény, Réka Z.
Nyiri, Gábor
author_sort Zichó, Krisztián
collection PubMed
description Fear-related memory traces are encoded by sparse populations of hippocampal principal neurons that are recruited based on their inhibitory–excitatory balance during memory formation. Later, the reactivation of the same principal neurons can recall the memory. The details of this mechanism are still unclear. Here, we investigated whether disinhibition could play a major role in this process. Using optogenetic behavioral experiments, we found that when fear was associated with the inhibition of mouse hippocampal somatostatin positive interneurons, the re-inhibition of the same interneurons could recall fear memory. Pontine nucleus incertus neurons selectively inhibit hippocampal somatostatin cells. We also found that when fear was associated with the activity of these incertus neurons or fibers, the reactivation of the same incertus neurons or fibers could also recall fear memory. These incertus neurons showed correlated activity with hippocampal principal neurons during memory recall and were strongly innervated by memory-related neocortical centers, from which the inputs could also control hippocampal disinhibition in vivo. Nonselective inhibition of these mouse hippocampal somatostatin or incertus neurons impaired memory recall. Our data suggest a novel disinhibition-based memory mechanism in the hippocampus that is supported by local somatostatin interneurons and their pontine brainstem inputs.
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spelling pubmed-102843812023-06-22 Fear memory recall involves hippocampal somatostatin interneurons Zichó, Krisztián Sos, Katalin E. Papp, Péter Barth, Albert M. Misák, Erik Orosz, Áron Mayer, Márton I. Sebestény, Réka Z. Nyiri, Gábor PLoS Biol Research Article Fear-related memory traces are encoded by sparse populations of hippocampal principal neurons that are recruited based on their inhibitory–excitatory balance during memory formation. Later, the reactivation of the same principal neurons can recall the memory. The details of this mechanism are still unclear. Here, we investigated whether disinhibition could play a major role in this process. Using optogenetic behavioral experiments, we found that when fear was associated with the inhibition of mouse hippocampal somatostatin positive interneurons, the re-inhibition of the same interneurons could recall fear memory. Pontine nucleus incertus neurons selectively inhibit hippocampal somatostatin cells. We also found that when fear was associated with the activity of these incertus neurons or fibers, the reactivation of the same incertus neurons or fibers could also recall fear memory. These incertus neurons showed correlated activity with hippocampal principal neurons during memory recall and were strongly innervated by memory-related neocortical centers, from which the inputs could also control hippocampal disinhibition in vivo. Nonselective inhibition of these mouse hippocampal somatostatin or incertus neurons impaired memory recall. Our data suggest a novel disinhibition-based memory mechanism in the hippocampus that is supported by local somatostatin interneurons and their pontine brainstem inputs. Public Library of Science 2023-06-08 /pmc/articles/PMC10284381/ /pubmed/37289847 http://dx.doi.org/10.1371/journal.pbio.3002154 Text en © 2023 Zichó et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zichó, Krisztián
Sos, Katalin E.
Papp, Péter
Barth, Albert M.
Misák, Erik
Orosz, Áron
Mayer, Márton I.
Sebestény, Réka Z.
Nyiri, Gábor
Fear memory recall involves hippocampal somatostatin interneurons
title Fear memory recall involves hippocampal somatostatin interneurons
title_full Fear memory recall involves hippocampal somatostatin interneurons
title_fullStr Fear memory recall involves hippocampal somatostatin interneurons
title_full_unstemmed Fear memory recall involves hippocampal somatostatin interneurons
title_short Fear memory recall involves hippocampal somatostatin interneurons
title_sort fear memory recall involves hippocampal somatostatin interneurons
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284381/
https://www.ncbi.nlm.nih.gov/pubmed/37289847
http://dx.doi.org/10.1371/journal.pbio.3002154
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