Rab26 restricts insulin secretion via sequestering Synaptotagmin-1

Rab26 is known to regulate multiple membrane trafficking events, but its role in insulin secretion in pancreatic β cells remains unclear despite it was first identified in the pancreas. In this study, we generated Rab26(-/-) mice through CRISPR/Cas9 technique. Surprisingly, insulin levels in the blo...

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Detalles Bibliográficos
Autores principales: Zhuang, Ruijuan, Zhou, Yuxia, Wang, Ziyan, Cao, Yating, Chen, Jun, Xu, Liju, Ren, Yandan, Zheng, Yige, Wei, Ziheng, Qiu, Hantian, Li, Liangcheng, Han, Yang, Yun, Ye, Chen, Xin, Hong, Wanjin, Wang, Tuanlao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284394/
https://www.ncbi.nlm.nih.gov/pubmed/37289842
http://dx.doi.org/10.1371/journal.pbio.3002142

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