Immunogenic proteins and potential delivery platforms for mpox virus vaccine development: A rapid review

Since May 2022, the mpox virus (MPXV) has spread worldwide and become a potential threat to global public health. Vaccines are important tools for preventing MPXV transmission and infection in the population. However, there are still no available potent and applicable vaccines specifically for MPXV....

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Detalles Bibliográficos
Autores principales: Wang, Yang, Yang, Kaiwen, Zhou, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284459/
https://www.ncbi.nlm.nih.gov/pubmed/37353117
http://dx.doi.org/10.1016/j.ijbiomac.2023.125515
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author Wang, Yang
Yang, Kaiwen
Zhou, Hao
author_facet Wang, Yang
Yang, Kaiwen
Zhou, Hao
author_sort Wang, Yang
collection PubMed
description Since May 2022, the mpox virus (MPXV) has spread worldwide and become a potential threat to global public health. Vaccines are important tools for preventing MPXV transmission and infection in the population. However, there are still no available potent and applicable vaccines specifically for MPXV. Herein, we highlight several potential vaccine targets for MPVX and emphasize potent immunogens, such as M1R, E8L, H3L, A29L, A35R, and B6R proteins. These proteins can be integrated into diverse vaccine platforms to elicit powerful B-cell and T-cell responses, thereby providing protective immunity against MPXV infection. Overall, research on the MPXV vaccine targets would provide valuable information for developing timely effective MPXV-specific vaccines.
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spelling pubmed-102844592023-06-22 Immunogenic proteins and potential delivery platforms for mpox virus vaccine development: A rapid review Wang, Yang Yang, Kaiwen Zhou, Hao Int J Biol Macromol Review Since May 2022, the mpox virus (MPXV) has spread worldwide and become a potential threat to global public health. Vaccines are important tools for preventing MPXV transmission and infection in the population. However, there are still no available potent and applicable vaccines specifically for MPXV. Herein, we highlight several potential vaccine targets for MPVX and emphasize potent immunogens, such as M1R, E8L, H3L, A29L, A35R, and B6R proteins. These proteins can be integrated into diverse vaccine platforms to elicit powerful B-cell and T-cell responses, thereby providing protective immunity against MPXV infection. Overall, research on the MPXV vaccine targets would provide valuable information for developing timely effective MPXV-specific vaccines. Elsevier B.V. 2023-06-21 /pmc/articles/PMC10284459/ /pubmed/37353117 http://dx.doi.org/10.1016/j.ijbiomac.2023.125515 Text en © 2023 Elsevier B.V. All rights reserved. Elsevier has created a Monkeypox Information Center (https://www.elsevier.com/connect/monkeypox-information-center) in response to the declared public health emergency of international concern, with free information in English on the monkeypox virus. The Monkeypox Information Center is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its monkeypox related research that is available on the Monkeypox Information Center - including this research content - immediately available in publicly funded repositories, with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the Monkeypox Information Center remains active.
spellingShingle Review
Wang, Yang
Yang, Kaiwen
Zhou, Hao
Immunogenic proteins and potential delivery platforms for mpox virus vaccine development: A rapid review
title Immunogenic proteins and potential delivery platforms for mpox virus vaccine development: A rapid review
title_full Immunogenic proteins and potential delivery platforms for mpox virus vaccine development: A rapid review
title_fullStr Immunogenic proteins and potential delivery platforms for mpox virus vaccine development: A rapid review
title_full_unstemmed Immunogenic proteins and potential delivery platforms for mpox virus vaccine development: A rapid review
title_short Immunogenic proteins and potential delivery platforms for mpox virus vaccine development: A rapid review
title_sort immunogenic proteins and potential delivery platforms for mpox virus vaccine development: a rapid review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284459/
https://www.ncbi.nlm.nih.gov/pubmed/37353117
http://dx.doi.org/10.1016/j.ijbiomac.2023.125515
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