Use of Pre-Operative Hemoglobin A1c to Predict Early Post-Operative Renal Failure and Infection Risks in Patients who are not Diabetics and Undergoing Elective off Pump Coronary Artery Bypass Graft Surgery

BACKGROUND: Recent studies have indicated that patients, both with and without diabetes with an increased HbA1c, have a higher rate of adverse outcomes following cardiac surgeries. Our study is focused on to evaluate the prognostic impact of admission value of HbA1c in non-diabetic patients for postoperative renal failure and infections. MATERIALS AND METHODS: Plasma HbA1c levels were collected from 200 consecutive nondiabetic patients who got admitted for elective off pump coronary artery bypass graft (CABG) procedure over a 2-year period under two groups, Group A whose HbA1c was < 6% at admission and Group B whose HbA1c was ≥6% and ≤6.4% at admission. After surgery, patients were followed up to see if they have got infection or renal failure as postoperative complication. Student’s unpaired t test was used to test the significance of difference between the quantitative variables, Yate’s and Fisher’s chi square tests were used for qualitative variables. RESULTS: We found early postoperative renal failure in 14 (3/96 in Group A and 11/104 in Group B) out of 200 patients (7%) and infection in 21 (8/96 in Group A and 13/104 in Group B) out of 200 patients (10.5%). After data analysis, it was noted that there is a positive correlation between HbA1c and postoperative renal failure (P = 0.0213) whereas no association was found between HbA1c and postoperative infections (P = 0.175) in patients undergoing off-pump CABG surgery. CONCLUSION: In patients without diabetes, a plasma HbA1c ≥6% was a significant independent predictor for early postoperative renal failure.