Disruption of proteome by an oncogenic fusion kinase alters metabolism in fibrolamellar hepatocellular carcinoma

Fibrolamellar hepatocellular carcinoma (FLC) is a usually lethal primary liver cancer driven by a somatic dysregulation of protein kinase A. We show that the proteome of FLC tumors is distinct from that of adjacent nontransformed tissue. These changes can account for some of the cell biological and...

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Detalles Bibliográficos
Autores principales: Levin, Solomon N., Tomasini, Michael D., Knox, James, Shirani, Mahsa, Shebl, Bassem, Requena, David, Clark, Jackson, Heissel, Søren, Alwaseem, Hanan, Surjan, Rodrigo, Lahasky, Ron, Molina, Henrik, Torbenson, Michael S., Lyons, Barbara, Migler, Rachael D., Coffino, Philip, Simon, Sanford M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284549/
https://www.ncbi.nlm.nih.gov/pubmed/37343102
http://dx.doi.org/10.1126/sciadv.adg7038

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