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Immune Thrombocytopenia: A Rare Adverse Event of Vancomycin Therapy

Vancomycin, a glycopeptide antibiotic, is widely used for Gram-positive cocci or bacilli bacteria-induced serious infections. Although considered safe and effective, it still causes adverse events. Vancomycin-induced immune thrombocytopenia is a rarely reported adverse event, manifesting from asympt...

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Autores principales: Obi, Emeka S, LNU, Devdat, Ehimwenma, Norense O, Tobalesi, Opeyemi, Iklaki, Winifred, Arslan, Faiza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284564/
https://www.ncbi.nlm.nih.gov/pubmed/37351249
http://dx.doi.org/10.7759/cureus.39348
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author Obi, Emeka S
LNU, Devdat
Ehimwenma, Norense O
Tobalesi, Opeyemi
Iklaki, Winifred
Arslan, Faiza
author_facet Obi, Emeka S
LNU, Devdat
Ehimwenma, Norense O
Tobalesi, Opeyemi
Iklaki, Winifred
Arslan, Faiza
author_sort Obi, Emeka S
collection PubMed
description Vancomycin, a glycopeptide antibiotic, is widely used for Gram-positive cocci or bacilli bacteria-induced serious infections. Although considered safe and effective, it still causes adverse events. Vancomycin-induced immune thrombocytopenia is a rarely reported adverse event, manifesting from asymptomatic thrombocytopenia to life-threatening bleeding. We underline a case of a 56-year-old male with a diabetic foot with an infected exudating purulent ulcer. He experienced a significant drop in platelet count after commencing vancomycin, and discontinuing vancomycin resulted in improved platelet count with positive vancomycin-induced anti-platelet antibodies. After ruling out other possible causes of thrombocytopenia, a presumptive diagnosis of vancomycin-induced thrombocytopenia was made.
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spelling pubmed-102845642023-06-22 Immune Thrombocytopenia: A Rare Adverse Event of Vancomycin Therapy Obi, Emeka S LNU, Devdat Ehimwenma, Norense O Tobalesi, Opeyemi Iklaki, Winifred Arslan, Faiza Cureus Internal Medicine Vancomycin, a glycopeptide antibiotic, is widely used for Gram-positive cocci or bacilli bacteria-induced serious infections. Although considered safe and effective, it still causes adverse events. Vancomycin-induced immune thrombocytopenia is a rarely reported adverse event, manifesting from asymptomatic thrombocytopenia to life-threatening bleeding. We underline a case of a 56-year-old male with a diabetic foot with an infected exudating purulent ulcer. He experienced a significant drop in platelet count after commencing vancomycin, and discontinuing vancomycin resulted in improved platelet count with positive vancomycin-induced anti-platelet antibodies. After ruling out other possible causes of thrombocytopenia, a presumptive diagnosis of vancomycin-induced thrombocytopenia was made. Cureus 2023-05-22 /pmc/articles/PMC10284564/ /pubmed/37351249 http://dx.doi.org/10.7759/cureus.39348 Text en Copyright © 2023, Obi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Obi, Emeka S
LNU, Devdat
Ehimwenma, Norense O
Tobalesi, Opeyemi
Iklaki, Winifred
Arslan, Faiza
Immune Thrombocytopenia: A Rare Adverse Event of Vancomycin Therapy
title Immune Thrombocytopenia: A Rare Adverse Event of Vancomycin Therapy
title_full Immune Thrombocytopenia: A Rare Adverse Event of Vancomycin Therapy
title_fullStr Immune Thrombocytopenia: A Rare Adverse Event of Vancomycin Therapy
title_full_unstemmed Immune Thrombocytopenia: A Rare Adverse Event of Vancomycin Therapy
title_short Immune Thrombocytopenia: A Rare Adverse Event of Vancomycin Therapy
title_sort immune thrombocytopenia: a rare adverse event of vancomycin therapy
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284564/
https://www.ncbi.nlm.nih.gov/pubmed/37351249
http://dx.doi.org/10.7759/cureus.39348
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