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Structural basis for FGF hormone signalling

α/βKlotho coreceptors simultaneously engage fibroblast growth factor (FGF) hormones (FGF19, FGF21 and FGF23)(1,2) and their cognate cell-surface FGF receptors (FGFR1–4) thereby stabilizing the endocrine FGF–FGFR complex(3–6). However, these hormones still require heparan sulfate (HS) proteoglycan as...

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Detalles Bibliográficos
Autores principales:	Chen, Lingfeng, Fu, Lili, Sun, Jingchuan, Huang, Zhiqiang, Fang, Mingzhen, Zinkle, Allen, Liu, Xin, Lu, Junliang, Pan, Zixiang, Wang, Yang, Liang, Guang, Li, Xiaokun, Chen, Gaozhi, Mohammadi, Moosa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284700/ https://www.ncbi.nlm.nih.gov/pubmed/37286607 http://dx.doi.org/10.1038/s41586-023-06155-9

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