The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity

In conjunction with previous studies, we have noted that ferroptosis, as an emerging mode of regulated cell death (RCD), is intimately related to anthracycline pharmacotherapy. Not only does ferroptosis significantly modulate tumour resistance and drug toxicity, which are core links of the relevant...

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Autores principales: Zhao, Jiazheng, Zhang, Ning, Ma, Xiaowei, Li, Ming, Feng, Helin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284859/
https://www.ncbi.nlm.nih.gov/pubmed/37344500
http://dx.doi.org/10.1038/s41420-023-01483-1
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author Zhao, Jiazheng
Zhang, Ning
Ma, Xiaowei
Li, Ming
Feng, Helin
author_facet Zhao, Jiazheng
Zhang, Ning
Ma, Xiaowei
Li, Ming
Feng, Helin
author_sort Zhao, Jiazheng
collection PubMed
description In conjunction with previous studies, we have noted that ferroptosis, as an emerging mode of regulated cell death (RCD), is intimately related to anthracycline pharmacotherapy. Not only does ferroptosis significantly modulate tumour resistance and drug toxicity, which are core links of the relevant chemotherapeutic process, but it also appears to play a conflicting role that has yet to be appreciated. By targeting the dual role of ferroptosis in anthracycline-based chemotherapy, this review aims to focus on the latest findings at this stage, identify the potential associations and provide novel perspectives for subsequent research directions and therapeutic strategies.
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spelling pubmed-102848592023-06-23 The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity Zhao, Jiazheng Zhang, Ning Ma, Xiaowei Li, Ming Feng, Helin Cell Death Discov Review Article In conjunction with previous studies, we have noted that ferroptosis, as an emerging mode of regulated cell death (RCD), is intimately related to anthracycline pharmacotherapy. Not only does ferroptosis significantly modulate tumour resistance and drug toxicity, which are core links of the relevant chemotherapeutic process, but it also appears to play a conflicting role that has yet to be appreciated. By targeting the dual role of ferroptosis in anthracycline-based chemotherapy, this review aims to focus on the latest findings at this stage, identify the potential associations and provide novel perspectives for subsequent research directions and therapeutic strategies. Nature Publishing Group UK 2023-06-21 /pmc/articles/PMC10284859/ /pubmed/37344500 http://dx.doi.org/10.1038/s41420-023-01483-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Zhao, Jiazheng
Zhang, Ning
Ma, Xiaowei
Li, Ming
Feng, Helin
The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity
title The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity
title_full The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity
title_fullStr The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity
title_full_unstemmed The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity
title_short The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity
title_sort dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284859/
https://www.ncbi.nlm.nih.gov/pubmed/37344500
http://dx.doi.org/10.1038/s41420-023-01483-1
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