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Molecular choreography of primer synthesis by the eukaryotic Pol α-primase

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The eukaryotic polymerase α (Pol α) synthesizes an RNA-DNA hybrid primer of 20–30 nucleotides. Pol α is composed of Pol1, Pol12, Primase 1 (Pri1), and Pri2. Pol1 and Pri1 contain the DNA polymerase and RNA primase activities, respectively. It has been unclear how Pol α hands over an RNA primer from...

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Detalles Bibliográficos
Autores principales:	Yuan, Zuanning, Georgescu, Roxana, Li, Huilin, O’Donnell, Michael E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284912/ https://www.ncbi.nlm.nih.gov/pubmed/37344454 http://dx.doi.org/10.1038/s41467-023-39441-1

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