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Are Measles-Mumps-Rubella (MMR) Antibodies Friends or Foes for Covid-19 Disease?

Many factors have been implicated in the pathogenesis and severity of COVID-19 pandemic. A wide variation in the susceptibility for SARS-CoV-2 infection among different population, gender and age has been observed. Multiple studies investigated the relationship between the antibody’s titre of previo...

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Autores principales: Salamony, Azza, Shamikh, Yara, Amer, Khaled, Elnagdy, Tarek, Elnakib, Mostafa, Yehia, Abd Allah, Hassan, Wael, Abdelsalam, Maha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284972/
https://www.ncbi.nlm.nih.gov/pubmed/37341786
http://dx.doi.org/10.1007/s00005-023-00680-1
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author Salamony, Azza
Shamikh, Yara
Amer, Khaled
Elnagdy, Tarek
Elnakib, Mostafa
Yehia, Abd Allah
Hassan, Wael
Abdelsalam, Maha
author_facet Salamony, Azza
Shamikh, Yara
Amer, Khaled
Elnagdy, Tarek
Elnakib, Mostafa
Yehia, Abd Allah
Hassan, Wael
Abdelsalam, Maha
author_sort Salamony, Azza
collection PubMed
description Many factors have been implicated in the pathogenesis and severity of COVID-19 pandemic. A wide variation in the susceptibility for SARS-CoV-2 infection among different population, gender and age has been observed. Multiple studies investigated the relationship between the antibody’s titre of previously vaccinated individuals and the susceptibility of coronavirus infection, to find a rapid effective therapy for this pandemic. This study focused on the association between measles-mumps-rubella (MMR) antibodies titre and the severity of COVID-19 infection. We aimed to investigate the correlation between the antibody’s titre of MMR and the SARS-CoV-2 infection susceptibility and disease severity, in a cohort of COVID-19 Egyptian patients, compared to a control group. MMR antibody titre was measured using enzyme Linked Immune Sorbent Assay; (ELISA) for 136 COVID-19 patients and 44 healthy individuals, as control group. There were high levels of measles and mumps antibodies titer in the deteriorating cases, which could not protect from SARS-CoV-2 infection. However, the rubella antibodies might protect from SARS-CoV-2 infection, but once the infection occurs, it may aggravate the risk of case deterioration. MMR antibodies could be used as a guideline for COVID-19 symptom-severity and, in turn, may be considered as an economic prognostic marker used for early protection from multiple autoimmune organ failure.
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spelling pubmed-102849722023-06-23 Are Measles-Mumps-Rubella (MMR) Antibodies Friends or Foes for Covid-19 Disease? Salamony, Azza Shamikh, Yara Amer, Khaled Elnagdy, Tarek Elnakib, Mostafa Yehia, Abd Allah Hassan, Wael Abdelsalam, Maha Arch Immunol Ther Exp (Warsz) Original Article Many factors have been implicated in the pathogenesis and severity of COVID-19 pandemic. A wide variation in the susceptibility for SARS-CoV-2 infection among different population, gender and age has been observed. Multiple studies investigated the relationship between the antibody’s titre of previously vaccinated individuals and the susceptibility of coronavirus infection, to find a rapid effective therapy for this pandemic. This study focused on the association between measles-mumps-rubella (MMR) antibodies titre and the severity of COVID-19 infection. We aimed to investigate the correlation between the antibody’s titre of MMR and the SARS-CoV-2 infection susceptibility and disease severity, in a cohort of COVID-19 Egyptian patients, compared to a control group. MMR antibody titre was measured using enzyme Linked Immune Sorbent Assay; (ELISA) for 136 COVID-19 patients and 44 healthy individuals, as control group. There were high levels of measles and mumps antibodies titer in the deteriorating cases, which could not protect from SARS-CoV-2 infection. However, the rubella antibodies might protect from SARS-CoV-2 infection, but once the infection occurs, it may aggravate the risk of case deterioration. MMR antibodies could be used as a guideline for COVID-19 symptom-severity and, in turn, may be considered as an economic prognostic marker used for early protection from multiple autoimmune organ failure. Springer International Publishing 2023-06-21 2023 /pmc/articles/PMC10284972/ /pubmed/37341786 http://dx.doi.org/10.1007/s00005-023-00680-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Salamony, Azza
Shamikh, Yara
Amer, Khaled
Elnagdy, Tarek
Elnakib, Mostafa
Yehia, Abd Allah
Hassan, Wael
Abdelsalam, Maha
Are Measles-Mumps-Rubella (MMR) Antibodies Friends or Foes for Covid-19 Disease?
title Are Measles-Mumps-Rubella (MMR) Antibodies Friends or Foes for Covid-19 Disease?
title_full Are Measles-Mumps-Rubella (MMR) Antibodies Friends or Foes for Covid-19 Disease?
title_fullStr Are Measles-Mumps-Rubella (MMR) Antibodies Friends or Foes for Covid-19 Disease?
title_full_unstemmed Are Measles-Mumps-Rubella (MMR) Antibodies Friends or Foes for Covid-19 Disease?
title_short Are Measles-Mumps-Rubella (MMR) Antibodies Friends or Foes for Covid-19 Disease?
title_sort are measles-mumps-rubella (mmr) antibodies friends or foes for covid-19 disease?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10284972/
https://www.ncbi.nlm.nih.gov/pubmed/37341786
http://dx.doi.org/10.1007/s00005-023-00680-1
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