Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field

Insulin-like growth factor-1 (IGF-1) is an active polypeptide protein that closely resembles the structural sequence of insulin and is involved in a variety of metabolic processes in the body. Decreased IGF-1 circulation levels are associated with an increased risk of stroke and a poorer prognosis,...

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Autores principales: Du, Hao, Xia, Jian, Huang, Lei, Zheng, Lan, Gu, Wenping, Yi, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285072/
https://www.ncbi.nlm.nih.gov/pubmed/37358957
http://dx.doi.org/10.3389/fnagi.2023.1190869
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author Du, Hao
Xia, Jian
Huang, Lei
Zheng, Lan
Gu, Wenping
Yi, Fang
author_facet Du, Hao
Xia, Jian
Huang, Lei
Zheng, Lan
Gu, Wenping
Yi, Fang
author_sort Du, Hao
collection PubMed
description Insulin-like growth factor-1 (IGF-1) is an active polypeptide protein that closely resembles the structural sequence of insulin and is involved in a variety of metabolic processes in the body. Decreased IGF-1 circulation levels are associated with an increased risk of stroke and a poorer prognosis, but the relationship with cerebral small vessel disease (cSVD) is unclear. Some studies found that the level of IGF-1 in patients with cSVD was significantly reduced, but the clinical significance and underlying mechanisms are unknown. This article reviews the correlation between IGF-1 and cerebrovascular disease and explores the potential relationship and mechanism between IGF-1 and cSVD.
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spelling pubmed-102850722023-06-23 Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field Du, Hao Xia, Jian Huang, Lei Zheng, Lan Gu, Wenping Yi, Fang Front Aging Neurosci Aging Neuroscience Insulin-like growth factor-1 (IGF-1) is an active polypeptide protein that closely resembles the structural sequence of insulin and is involved in a variety of metabolic processes in the body. Decreased IGF-1 circulation levels are associated with an increased risk of stroke and a poorer prognosis, but the relationship with cerebral small vessel disease (cSVD) is unclear. Some studies found that the level of IGF-1 in patients with cSVD was significantly reduced, but the clinical significance and underlying mechanisms are unknown. This article reviews the correlation between IGF-1 and cerebrovascular disease and explores the potential relationship and mechanism between IGF-1 and cSVD. Frontiers Media S.A. 2023-06-08 /pmc/articles/PMC10285072/ /pubmed/37358957 http://dx.doi.org/10.3389/fnagi.2023.1190869 Text en Copyright © 2023 Du, Xia, Huang, Zheng, Gu and Yi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Du, Hao
Xia, Jian
Huang, Lei
Zheng, Lan
Gu, Wenping
Yi, Fang
Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field
title Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field
title_full Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field
title_fullStr Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field
title_full_unstemmed Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field
title_short Relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field
title_sort relationship between insulin-like growth factor-1 and cerebral small vessel disease and its mechanisms: advances in the field
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285072/
https://www.ncbi.nlm.nih.gov/pubmed/37358957
http://dx.doi.org/10.3389/fnagi.2023.1190869
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