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Intestinal fungi and antifungal secretory immunoglobulin A in Crohn’s disease
The human gastrointestinal tract harbors trillions of commensal microorganisms. Emerging evidence points to a possible link between intestinal fungal dysbiosis and antifungal mucosal immunity in inflammatory bowel disease, especially in Crohn’s disease (CD). As a protective factor for the gut mucosa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285161/ https://www.ncbi.nlm.nih.gov/pubmed/37359518 http://dx.doi.org/10.3389/fimmu.2023.1177504 |
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author | Sun, Meng Ju, Jingyi Xu, Hongzhen Wang, Yufang |
author_facet | Sun, Meng Ju, Jingyi Xu, Hongzhen Wang, Yufang |
author_sort | Sun, Meng |
collection | PubMed |
description | The human gastrointestinal tract harbors trillions of commensal microorganisms. Emerging evidence points to a possible link between intestinal fungal dysbiosis and antifungal mucosal immunity in inflammatory bowel disease, especially in Crohn’s disease (CD). As a protective factor for the gut mucosa, secretory immunoglobulin A (SIgA) prevents bacteria from invading the intestinal epithelium and maintains a healthy microbiota community. In recent years, the roles of antifungal SIgA antibodies in mucosal immunity, including the regulation of intestinal immunity binding to hyphae-associated virulence factors, are becoming increasingly recognized. Here we review the current knowledge on intestinal fungal dysbiosis and antifungal mucosal immunity in healthy individuals and in patients with CD, discuss the factors governing antifungal SIgA responses in the intestinal mucosa in the latter group, and highlight potential antifungal vaccines targeting SIgA to prevent CD. |
format | Online Article Text |
id | pubmed-10285161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-102851612023-06-23 Intestinal fungi and antifungal secretory immunoglobulin A in Crohn’s disease Sun, Meng Ju, Jingyi Xu, Hongzhen Wang, Yufang Front Immunol Immunology The human gastrointestinal tract harbors trillions of commensal microorganisms. Emerging evidence points to a possible link between intestinal fungal dysbiosis and antifungal mucosal immunity in inflammatory bowel disease, especially in Crohn’s disease (CD). As a protective factor for the gut mucosa, secretory immunoglobulin A (SIgA) prevents bacteria from invading the intestinal epithelium and maintains a healthy microbiota community. In recent years, the roles of antifungal SIgA antibodies in mucosal immunity, including the regulation of intestinal immunity binding to hyphae-associated virulence factors, are becoming increasingly recognized. Here we review the current knowledge on intestinal fungal dysbiosis and antifungal mucosal immunity in healthy individuals and in patients with CD, discuss the factors governing antifungal SIgA responses in the intestinal mucosa in the latter group, and highlight potential antifungal vaccines targeting SIgA to prevent CD. Frontiers Media S.A. 2023-06-08 /pmc/articles/PMC10285161/ /pubmed/37359518 http://dx.doi.org/10.3389/fimmu.2023.1177504 Text en Copyright © 2023 Sun, Ju, Xu and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Sun, Meng Ju, Jingyi Xu, Hongzhen Wang, Yufang Intestinal fungi and antifungal secretory immunoglobulin A in Crohn’s disease |
title | Intestinal fungi and antifungal secretory immunoglobulin A in Crohn’s disease |
title_full | Intestinal fungi and antifungal secretory immunoglobulin A in Crohn’s disease |
title_fullStr | Intestinal fungi and antifungal secretory immunoglobulin A in Crohn’s disease |
title_full_unstemmed | Intestinal fungi and antifungal secretory immunoglobulin A in Crohn’s disease |
title_short | Intestinal fungi and antifungal secretory immunoglobulin A in Crohn’s disease |
title_sort | intestinal fungi and antifungal secretory immunoglobulin a in crohn’s disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285161/ https://www.ncbi.nlm.nih.gov/pubmed/37359518 http://dx.doi.org/10.3389/fimmu.2023.1177504 |
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