Single-cell transcriptomics combined with proteomics of intrathecal IgG reveal transcriptional heterogeneity of oligoclonal IgG-secreting cells in multiple sclerosis

The phenotypes of B lineage cells that produce oligoclonal IgG in multiple sclerosis have not been unequivocally determined. Here, we utilized single-cell RNA-seq data of intrathecal B lineage cells in combination with mass spectrometry of intrathecally synthesized IgG to identify its cellular sourc...

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Detalles Bibliográficos
Autores principales: Polak, Justyna, Wagnerberger, Johanna H., Torsetnes, Silje Bøen, Lindeman, Ida, Høglund, Rune A. Aa., Vartdal, Frode, Sollid, Ludvig M., Lossius, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285169/
https://www.ncbi.nlm.nih.gov/pubmed/37362001
http://dx.doi.org/10.3389/fncel.2023.1189709

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