Cargando…

Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis

BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders. OBJECTIVE: This meta-analysis was conducted to det...

Descripción completa

Detalles Bibliográficos
Autores principales: Sobhan Bahreiny, Seyed, Harooni, Elnaz, Reza Dabbagh, Mohammad, Ebrahimi, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Knowledge E 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285194/
https://www.ncbi.nlm.nih.gov/pubmed/37362092
http://dx.doi.org/10.18502/ijrm.v21i5.13470
_version_ 1785061558476341248
author Sobhan Bahreiny, Seyed
Harooni, Elnaz
Reza Dabbagh, Mohammad
Ebrahimi, Reza
author_facet Sobhan Bahreiny, Seyed
Harooni, Elnaz
Reza Dabbagh, Mohammad
Ebrahimi, Reza
author_sort Sobhan Bahreiny, Seyed
collection PubMed
description BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders. OBJECTIVE: This meta-analysis was conducted to determine the relationship between circulating preptin levels and PCOS. MATERIALS AND METHODS: A systematic review and meta-analysis was performed to identify relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and the Google Scholar search engine, using a predefined search strategy. A random-effects model was used to combine standard mean difference (SMD) and 95% CI to compare results between groups. Meta-regression and subgroup analysis were also performed to reveal the sources of heterogeneity. RESULTS: The meta-analysis encompassed a total of 8 studies and 582 participants. The results indicate a statistically significant association between PCOS and serum preptin levels, with a pooled standardized mean difference (SMD = 1.35; 95% CI]: 0.63-2.08; p [Formula: see text] 0.001). Further analysis suggested a significant difference in serum preptin levels between women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 2.40; 95% CI: 1.17-3.63; p [Formula: see text] 0.001) within the subgroup. CONCLUSION: Our meta-analysis shows that increased serum preptin levels are associated with PCOS, suggesting that preptin may be related to the pathogenesis of PCOS and may be recognized as a novel diagnostic biomarker for PCOS. However, further studies are needed to confirm our results.
format Online
Article
Text
id pubmed-10285194
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Knowledge E
record_format MEDLINE/PubMed
spelling pubmed-102851942023-06-23 Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis Sobhan Bahreiny, Seyed Harooni, Elnaz Reza Dabbagh, Mohammad Ebrahimi, Reza Int J Reprod Biomed Review Article BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders. OBJECTIVE: This meta-analysis was conducted to determine the relationship between circulating preptin levels and PCOS. MATERIALS AND METHODS: A systematic review and meta-analysis was performed to identify relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and the Google Scholar search engine, using a predefined search strategy. A random-effects model was used to combine standard mean difference (SMD) and 95% CI to compare results between groups. Meta-regression and subgroup analysis were also performed to reveal the sources of heterogeneity. RESULTS: The meta-analysis encompassed a total of 8 studies and 582 participants. The results indicate a statistically significant association between PCOS and serum preptin levels, with a pooled standardized mean difference (SMD = 1.35; 95% CI]: 0.63-2.08; p [Formula: see text] 0.001). Further analysis suggested a significant difference in serum preptin levels between women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 2.40; 95% CI: 1.17-3.63; p [Formula: see text] 0.001) within the subgroup. CONCLUSION: Our meta-analysis shows that increased serum preptin levels are associated with PCOS, suggesting that preptin may be related to the pathogenesis of PCOS and may be recognized as a novel diagnostic biomarker for PCOS. However, further studies are needed to confirm our results. Knowledge E 2023-05-12 /pmc/articles/PMC10285194/ /pubmed/37362092 http://dx.doi.org/10.18502/ijrm.v21i5.13470 Text en Copyright © 2023 Bahreiny et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sobhan Bahreiny, Seyed
Harooni, Elnaz
Reza Dabbagh, Mohammad
Ebrahimi, Reza
Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis
title Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis
title_full Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis
title_fullStr Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis
title_full_unstemmed Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis
title_short Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis
title_sort circulating serum preptin levels in women with polycystic ovary syndrome: a systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285194/
https://www.ncbi.nlm.nih.gov/pubmed/37362092
http://dx.doi.org/10.18502/ijrm.v21i5.13470
work_keys_str_mv AT sobhanbahreinyseyed circulatingserumpreptinlevelsinwomenwithpolycysticovarysyndromeasystematicreviewandmetaanalysis
AT haroonielnaz circulatingserumpreptinlevelsinwomenwithpolycysticovarysyndromeasystematicreviewandmetaanalysis
AT rezadabbaghmohammad circulatingserumpreptinlevelsinwomenwithpolycysticovarysyndromeasystematicreviewandmetaanalysis
AT ebrahimireza circulatingserumpreptinlevelsinwomenwithpolycysticovarysyndromeasystematicreviewandmetaanalysis