Cargando…
Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis
BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders. OBJECTIVE: This meta-analysis was conducted to det...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Knowledge E
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285194/ https://www.ncbi.nlm.nih.gov/pubmed/37362092 http://dx.doi.org/10.18502/ijrm.v21i5.13470 |
_version_ | 1785061558476341248 |
---|---|
author | Sobhan Bahreiny, Seyed Harooni, Elnaz Reza Dabbagh, Mohammad Ebrahimi, Reza |
author_facet | Sobhan Bahreiny, Seyed Harooni, Elnaz Reza Dabbagh, Mohammad Ebrahimi, Reza |
author_sort | Sobhan Bahreiny, Seyed |
collection | PubMed |
description | BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders. OBJECTIVE: This meta-analysis was conducted to determine the relationship between circulating preptin levels and PCOS. MATERIALS AND METHODS: A systematic review and meta-analysis was performed to identify relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and the Google Scholar search engine, using a predefined search strategy. A random-effects model was used to combine standard mean difference (SMD) and 95% CI to compare results between groups. Meta-regression and subgroup analysis were also performed to reveal the sources of heterogeneity. RESULTS: The meta-analysis encompassed a total of 8 studies and 582 participants. The results indicate a statistically significant association between PCOS and serum preptin levels, with a pooled standardized mean difference (SMD = 1.35; 95% CI]: 0.63-2.08; p [Formula: see text] 0.001). Further analysis suggested a significant difference in serum preptin levels between women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 2.40; 95% CI: 1.17-3.63; p [Formula: see text] 0.001) within the subgroup. CONCLUSION: Our meta-analysis shows that increased serum preptin levels are associated with PCOS, suggesting that preptin may be related to the pathogenesis of PCOS and may be recognized as a novel diagnostic biomarker for PCOS. However, further studies are needed to confirm our results. |
format | Online Article Text |
id | pubmed-10285194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Knowledge E |
record_format | MEDLINE/PubMed |
spelling | pubmed-102851942023-06-23 Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis Sobhan Bahreiny, Seyed Harooni, Elnaz Reza Dabbagh, Mohammad Ebrahimi, Reza Int J Reprod Biomed Review Article BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder with complex pathogenesis and metabolic complications, such as insulin resistance. Among the new markers, preptin seems to play a significant role in metabolic disorders. OBJECTIVE: This meta-analysis was conducted to determine the relationship between circulating preptin levels and PCOS. MATERIALS AND METHODS: A systematic review and meta-analysis was performed to identify relevant articles in electronic databases such as PubMed, Web of Science, Scopus, Cochrane, EMBASE, and the Google Scholar search engine, using a predefined search strategy. A random-effects model was used to combine standard mean difference (SMD) and 95% CI to compare results between groups. Meta-regression and subgroup analysis were also performed to reveal the sources of heterogeneity. RESULTS: The meta-analysis encompassed a total of 8 studies and 582 participants. The results indicate a statistically significant association between PCOS and serum preptin levels, with a pooled standardized mean difference (SMD = 1.35; 95% CI]: 0.63-2.08; p [Formula: see text] 0.001). Further analysis suggested a significant difference in serum preptin levels between women with PCOS and higher homeostatic model assessment for insulin resistance ratio (SMD = 2.40; 95% CI: 1.17-3.63; p [Formula: see text] 0.001) within the subgroup. CONCLUSION: Our meta-analysis shows that increased serum preptin levels are associated with PCOS, suggesting that preptin may be related to the pathogenesis of PCOS and may be recognized as a novel diagnostic biomarker for PCOS. However, further studies are needed to confirm our results. Knowledge E 2023-05-12 /pmc/articles/PMC10285194/ /pubmed/37362092 http://dx.doi.org/10.18502/ijrm.v21i5.13470 Text en Copyright © 2023 Bahreiny et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sobhan Bahreiny, Seyed Harooni, Elnaz Reza Dabbagh, Mohammad Ebrahimi, Reza Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis |
title | Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis |
title_full | Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis |
title_fullStr | Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis |
title_full_unstemmed | Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis |
title_short | Circulating serum preptin levels in women with polycystic ovary syndrome: A systematic review and meta-analysis |
title_sort | circulating serum preptin levels in women with polycystic ovary syndrome: a systematic review and meta-analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285194/ https://www.ncbi.nlm.nih.gov/pubmed/37362092 http://dx.doi.org/10.18502/ijrm.v21i5.13470 |
work_keys_str_mv | AT sobhanbahreinyseyed circulatingserumpreptinlevelsinwomenwithpolycysticovarysyndromeasystematicreviewandmetaanalysis AT haroonielnaz circulatingserumpreptinlevelsinwomenwithpolycysticovarysyndromeasystematicreviewandmetaanalysis AT rezadabbaghmohammad circulatingserumpreptinlevelsinwomenwithpolycysticovarysyndromeasystematicreviewandmetaanalysis AT ebrahimireza circulatingserumpreptinlevelsinwomenwithpolycysticovarysyndromeasystematicreviewandmetaanalysis |