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Survival associated miRNA signature in patients with head and neck carcinomas
Head and neck carcinoma (HNSC) is often diagnosed at advanced stage, incurring poor patient outcome. Despite of advances in chemoradiation and surgery approaches, limited improvements in survival rates of HNSC have been observed over the last decade. Accumulating evidences have demonstrated the impo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285236/ https://www.ncbi.nlm.nih.gov/pubmed/37360084 http://dx.doi.org/10.1016/j.heliyon.2023.e17218 |
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author | Yerukala Sathipati, Srinivasulu Ho, Shinn-Ying |
author_facet | Yerukala Sathipati, Srinivasulu Ho, Shinn-Ying |
author_sort | Yerukala Sathipati, Srinivasulu |
collection | PubMed |
description | Head and neck carcinoma (HNSC) is often diagnosed at advanced stage, incurring poor patient outcome. Despite of advances in chemoradiation and surgery approaches, limited improvements in survival rates of HNSC have been observed over the last decade. Accumulating evidences have demonstrated the importance of microRNAs (miRNAs) in carcinogenesis. In this context, we sought to identify a miRNA signature associated with the survival time in patients with HNSC. This study proposed a survival estimation method called HNSC-Sig that identified a miRNA signature consists of 25 miRNAs associated with the survival in 133 patients with HNSC. HNSC-Sig achieved 10-fold cross validation a mean correlation coefficient and a mean absolute error of 0.85 ± 0.01 and 0.46 ± 0.02 years, respectively, between actual and estimated survival times. The survival analysis revealed that five miRNAs, hsa-miR-3605-3p, hsa-miR-629-3p, hsa-miR-3127-5p, hsa-miR-497-5p, and hsa-miR-374a-5p, were significantly associated with prognosis in patients with HNSC. Comparing the relative expression difference of top 10 prioritized miRNAs, eight miRNAs, hsa-miR-629-3p, hsa-miR-3127-5p, hsa-miR-221-3p, hsa-miR-501-5p, hsa-miR-491-5p, hsa-miR-149-3p, hsa-miR-3934-5p, and hsa-miR-3170, were significantly expressed between cancer and normal groups. In addition, biological relevance, disease association, and target interactions of the miRNA signature were discussed. Our results suggest that identified miRNA signature have potential to serve as biomarker for diagnosis and clinical practice in HNSC. |
format | Online Article Text |
id | pubmed-10285236 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-102852362023-06-23 Survival associated miRNA signature in patients with head and neck carcinomas Yerukala Sathipati, Srinivasulu Ho, Shinn-Ying Heliyon Research Article Head and neck carcinoma (HNSC) is often diagnosed at advanced stage, incurring poor patient outcome. Despite of advances in chemoradiation and surgery approaches, limited improvements in survival rates of HNSC have been observed over the last decade. Accumulating evidences have demonstrated the importance of microRNAs (miRNAs) in carcinogenesis. In this context, we sought to identify a miRNA signature associated with the survival time in patients with HNSC. This study proposed a survival estimation method called HNSC-Sig that identified a miRNA signature consists of 25 miRNAs associated with the survival in 133 patients with HNSC. HNSC-Sig achieved 10-fold cross validation a mean correlation coefficient and a mean absolute error of 0.85 ± 0.01 and 0.46 ± 0.02 years, respectively, between actual and estimated survival times. The survival analysis revealed that five miRNAs, hsa-miR-3605-3p, hsa-miR-629-3p, hsa-miR-3127-5p, hsa-miR-497-5p, and hsa-miR-374a-5p, were significantly associated with prognosis in patients with HNSC. Comparing the relative expression difference of top 10 prioritized miRNAs, eight miRNAs, hsa-miR-629-3p, hsa-miR-3127-5p, hsa-miR-221-3p, hsa-miR-501-5p, hsa-miR-491-5p, hsa-miR-149-3p, hsa-miR-3934-5p, and hsa-miR-3170, were significantly expressed between cancer and normal groups. In addition, biological relevance, disease association, and target interactions of the miRNA signature were discussed. Our results suggest that identified miRNA signature have potential to serve as biomarker for diagnosis and clinical practice in HNSC. Elsevier 2023-06-12 /pmc/articles/PMC10285236/ /pubmed/37360084 http://dx.doi.org/10.1016/j.heliyon.2023.e17218 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Yerukala Sathipati, Srinivasulu Ho, Shinn-Ying Survival associated miRNA signature in patients with head and neck carcinomas |
title | Survival associated miRNA signature in patients with head and neck carcinomas |
title_full | Survival associated miRNA signature in patients with head and neck carcinomas |
title_fullStr | Survival associated miRNA signature in patients with head and neck carcinomas |
title_full_unstemmed | Survival associated miRNA signature in patients with head and neck carcinomas |
title_short | Survival associated miRNA signature in patients with head and neck carcinomas |
title_sort | survival associated mirna signature in patients with head and neck carcinomas |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285236/ https://www.ncbi.nlm.nih.gov/pubmed/37360084 http://dx.doi.org/10.1016/j.heliyon.2023.e17218 |
work_keys_str_mv | AT yerukalasathipatisrinivasulu survivalassociatedmirnasignatureinpatientswithheadandneckcarcinomas AT hoshinnying survivalassociatedmirnasignatureinpatientswithheadandneckcarcinomas |