The FAM86 domain of FAM86A confers substrate specificity to promote EEF2-Lys525 methylation

FAM86A is a class I lysine methyltransferase (KMT) that generates trimethylation on the eukaryotic translation elongation factor 2 (EEF2) at Lys525. Publicly available data from The Cancer Dependency Map project indicate high dependence of hundreds of human cancer cell lines on FAM86A expression. Th...

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Detalles Bibliográficos
Autores principales: Francis, Joel William, Shao, Zengyu, Narkhede, Pradnya, Trinh, Annie Truc, Lu, Jiuwei, Song, Jikui, Gozani, Or
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285254/
https://www.ncbi.nlm.nih.gov/pubmed/37209825
http://dx.doi.org/10.1016/j.jbc.2023.104842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285254/
https://www.ncbi.nlm.nih.gov/pubmed/37209825
http://dx.doi.org/10.1016/j.jbc.2023.104842

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