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Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1

Cytochrome P450 (P450, CYP) family 51 enzymes catalyze the 14α-demethylation of sterols, leading to critical products used for membranes and the production of steroids, as well as signaling molecules. In mammals, P450 51 catalyzes the 3-step, 6-electron oxidation of lanosterol to form (4β,5α)-4,4-di...

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Detalles Bibliográficos
Autores principales:	McCarty, Kevin D., Sullivan, Molly E., Tateishi, Yasuhiro, Hargrove, Tatiana Y., Lepesheva, Galina I., Guengerich, F. Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285260/ https://www.ncbi.nlm.nih.gov/pubmed/37209823 http://dx.doi.org/10.1016/j.jbc.2023.104841

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