Inflammasome activation and metabolic remodelling in p16‐positive aging cells aggravates high‐fat diet‐induced lung fibrosis by inhibiting NEDD4L‐mediated K48‐polyubiquitin‐dependent degradation of SGK1

BACKGROUND: Chronic changes caused by a high‐fat diet (HFD) may be associated with weakened lung function in obese patients. However, few studies have focused on the role of senescent cells in HFD‐induced pulmonary fibrosis. This study aimed to determine whether (i) obesity causes the accumulation o...

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Detalles Bibliográficos
Autores principales: Gu, Xin, Meng, Haoyu, Peng, Chengyi, Lin, Shiyu, Li, Baihong, Zhao, Lin, Yang, Xue, Wang, Guangyan, Cai, Wenyuan, Zhou, Jiawen, Liu, Shuiyuan, Wu, Peng, Du, Yingqiang, Jin, Jianliang, Wang, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285269/
https://www.ncbi.nlm.nih.gov/pubmed/37345264
http://dx.doi.org/10.1002/ctm2.1308

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