Case Report: Treatment of porphyria cutanea tarda with low dose hydroxychloroquine

Background: Porphyria cutanea tarda (PCT) is a complex metabolic disease resulting from altered activity of the enzyme uroporphyrinogen decarboxylase (UROD) in the liver resulting in accumulation of uroporphyrin. PCT presents as a blistering photodermatitis with skin fragility, vesicles, scarring an...

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Autores principales: Awad, Andrew, Nirenberg, Alexander, Sinclair, Rodney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285345/
https://www.ncbi.nlm.nih.gov/pubmed/37360939
http://dx.doi.org/10.12688/f1000research.124022.1
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author Awad, Andrew
Nirenberg, Alexander
Sinclair, Rodney
author_facet Awad, Andrew
Nirenberg, Alexander
Sinclair, Rodney
author_sort Awad, Andrew
collection PubMed
description Background: Porphyria cutanea tarda (PCT) is a complex metabolic disease resulting from altered activity of the enzyme uroporphyrinogen decarboxylase (UROD) in the liver resulting in accumulation of uroporphyrin. PCT presents as a blistering photodermatitis with skin fragility, vesicles, scarring and milia. Case: We report a case of PCT in a 67-year-old man with hemochromatosis (HFE) gene mutation who, following a major syncopal episode in response to venesection was commenced on low dose hydroxychloroquine. Conclusions: Low dose hydroxychloroquine provided a safe and effective alternative to venesection in this patient who was needle phobic.
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spelling pubmed-102853452023-06-23 Case Report: Treatment of porphyria cutanea tarda with low dose hydroxychloroquine Awad, Andrew Nirenberg, Alexander Sinclair, Rodney F1000Res Case Report Background: Porphyria cutanea tarda (PCT) is a complex metabolic disease resulting from altered activity of the enzyme uroporphyrinogen decarboxylase (UROD) in the liver resulting in accumulation of uroporphyrin. PCT presents as a blistering photodermatitis with skin fragility, vesicles, scarring and milia. Case: We report a case of PCT in a 67-year-old man with hemochromatosis (HFE) gene mutation who, following a major syncopal episode in response to venesection was commenced on low dose hydroxychloroquine. Conclusions: Low dose hydroxychloroquine provided a safe and effective alternative to venesection in this patient who was needle phobic. F1000 Research Limited 2022-08-17 /pmc/articles/PMC10285345/ /pubmed/37360939 http://dx.doi.org/10.12688/f1000research.124022.1 Text en Copyright: © 2022 Awad A et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Awad, Andrew
Nirenberg, Alexander
Sinclair, Rodney
Case Report: Treatment of porphyria cutanea tarda with low dose hydroxychloroquine
title Case Report: Treatment of porphyria cutanea tarda with low dose hydroxychloroquine
title_full Case Report: Treatment of porphyria cutanea tarda with low dose hydroxychloroquine
title_fullStr Case Report: Treatment of porphyria cutanea tarda with low dose hydroxychloroquine
title_full_unstemmed Case Report: Treatment of porphyria cutanea tarda with low dose hydroxychloroquine
title_short Case Report: Treatment of porphyria cutanea tarda with low dose hydroxychloroquine
title_sort case report: treatment of porphyria cutanea tarda with low dose hydroxychloroquine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285345/
https://www.ncbi.nlm.nih.gov/pubmed/37360939
http://dx.doi.org/10.12688/f1000research.124022.1
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