Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo

Zinc (Zn(2+)) is considered as important mediator of immune cell function, thrombosis and haemostasis. However, our understanding of the transport mechanisms that regulate Zn(2+) homeostasis in platelets is limited. Zn(2+) transporters, ZIPs and ZnTs, are widely expressed in eukaryotic cells. Using...

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Detalles Bibliográficos
Autores principales: Elgheznawy, Amro, Öftering, Patricia, Englert, Maximilian, Mott, Kristina, Kaiser, Friederike, Kusch, Charly, Gbureck, Uwe, Bösl, Michael R., Schulze, Harald, Nieswandt, Bernhard, Vögtle, Timo, Hermanns, Heike M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285393/
https://www.ncbi.nlm.nih.gov/pubmed/37359521
http://dx.doi.org/10.3389/fimmu.2023.1197894

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