Case Report: Intercurrent infections in COVID-19-induced sustained immunodepression: is interferon gamma a suitable drug?

Acute immuno-depression syndrome (AIDs) had been observed in many life-threatening conditions leading to the Intensive Care Unit. and is associated with recurrent secondary infections. We report one COVID-19 patient with a severe ARDS, demonstrating acute immunodepression syndrome lasting for severa...

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Autores principales: De Waard, Aurianne, Lefebvre, Laurent, Textoris, Julien, Payen, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285411/
https://www.ncbi.nlm.nih.gov/pubmed/37359519
http://dx.doi.org/10.3389/fimmu.2023.1183665
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author De Waard, Aurianne
Lefebvre, Laurent
Textoris, Julien
Payen, Didier
author_facet De Waard, Aurianne
Lefebvre, Laurent
Textoris, Julien
Payen, Didier
author_sort De Waard, Aurianne
collection PubMed
description Acute immuno-depression syndrome (AIDs) had been observed in many life-threatening conditions leading to the Intensive Care Unit. and is associated with recurrent secondary infections. We report one COVID-19 patient with a severe ARDS, demonstrating acute immunodepression syndrome lasting for several weeks. The occurrence of secondary infections despite long treatment by antibiotics led to combined interferon γ (IFNγ) as reported previously. The response to IFNγ was evaluated by the flowcytometry HLA-DR expression on circulating monocytes, which was repeated from time to time. The severe COVID-19 patients responded well to IFNγ without adverse events.
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spelling pubmed-102854112023-06-23 Case Report: Intercurrent infections in COVID-19-induced sustained immunodepression: is interferon gamma a suitable drug? De Waard, Aurianne Lefebvre, Laurent Textoris, Julien Payen, Didier Front Immunol Immunology Acute immuno-depression syndrome (AIDs) had been observed in many life-threatening conditions leading to the Intensive Care Unit. and is associated with recurrent secondary infections. We report one COVID-19 patient with a severe ARDS, demonstrating acute immunodepression syndrome lasting for several weeks. The occurrence of secondary infections despite long treatment by antibiotics led to combined interferon γ (IFNγ) as reported previously. The response to IFNγ was evaluated by the flowcytometry HLA-DR expression on circulating monocytes, which was repeated from time to time. The severe COVID-19 patients responded well to IFNγ without adverse events. Frontiers Media S.A. 2023-06-08 /pmc/articles/PMC10285411/ /pubmed/37359519 http://dx.doi.org/10.3389/fimmu.2023.1183665 Text en Copyright © 2023 De Waard, Lefebvre, Textoris and Payen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
De Waard, Aurianne
Lefebvre, Laurent
Textoris, Julien
Payen, Didier
Case Report: Intercurrent infections in COVID-19-induced sustained immunodepression: is interferon gamma a suitable drug?
title Case Report: Intercurrent infections in COVID-19-induced sustained immunodepression: is interferon gamma a suitable drug?
title_full Case Report: Intercurrent infections in COVID-19-induced sustained immunodepression: is interferon gamma a suitable drug?
title_fullStr Case Report: Intercurrent infections in COVID-19-induced sustained immunodepression: is interferon gamma a suitable drug?
title_full_unstemmed Case Report: Intercurrent infections in COVID-19-induced sustained immunodepression: is interferon gamma a suitable drug?
title_short Case Report: Intercurrent infections in COVID-19-induced sustained immunodepression: is interferon gamma a suitable drug?
title_sort case report: intercurrent infections in covid-19-induced sustained immunodepression: is interferon gamma a suitable drug?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285411/
https://www.ncbi.nlm.nih.gov/pubmed/37359519
http://dx.doi.org/10.3389/fimmu.2023.1183665
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