Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson

Synchronous tumors of the rectum and anus are sporadic. Most cases in the literature are rectal adenocarcinomas with concomitant anal squamous cell carcinoma. To date, only two cases of concomitant squamous cell carcinomas of the rectum and anus are reported, and both were treated with up-front surg...

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Detalles Bibliográficos
Autores principales: Ciardiello, Davide, Del Tufo, Sara, Parente, Paola, Gravina, Antonietta Gerarda, Selvaggi, Francesco, Panarese, Iacopo, Franco, Renato, Caterino, Michele, Martini, Giulia, Ciardiello, Fortunato, Grassi, Roberto, Cappabianca, Salvatore, Reginelli, Alfonso, Martinelli, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285495/
https://www.ncbi.nlm.nih.gov/pubmed/37361596
http://dx.doi.org/10.3389/fonc.2023.1187623
Descripción
Sumario:Synchronous tumors of the rectum and anus are sporadic. Most cases in the literature are rectal adenocarcinomas with concomitant anal squamous cell carcinoma. To date, only two cases of concomitant squamous cell carcinomas of the rectum and anus are reported, and both were treated with up-front surgery and received abdominoperineal resection with colostomy. Here, we report the first case in the literature of a patient with synchronous HPV-positive squamous cell carcinoma of the rectum and anus treated with definitive chemoradiotherapy with curative intent. The clinical-radiological evaluation demonstrated complete tumor regression. After 2 years of follow-up, no evidence of recurrence was observed.

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