Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson

Synchronous tumors of the rectum and anus are sporadic. Most cases in the literature are rectal adenocarcinomas with concomitant anal squamous cell carcinoma. To date, only two cases of concomitant squamous cell carcinomas of the rectum and anus are reported, and both were treated with up-front surg...

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Autores principales: Ciardiello, Davide, Del Tufo, Sara, Parente, Paola, Gravina, Antonietta Gerarda, Selvaggi, Francesco, Panarese, Iacopo, Franco, Renato, Caterino, Michele, Martini, Giulia, Ciardiello, Fortunato, Grassi, Roberto, Cappabianca, Salvatore, Reginelli, Alfonso, Martinelli, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285495/
https://www.ncbi.nlm.nih.gov/pubmed/37361596
http://dx.doi.org/10.3389/fonc.2023.1187623
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author Ciardiello, Davide
Del Tufo, Sara
Parente, Paola
Gravina, Antonietta Gerarda
Selvaggi, Francesco
Panarese, Iacopo
Franco, Renato
Caterino, Michele
Martini, Giulia
Ciardiello, Fortunato
Grassi, Roberto
Cappabianca, Salvatore
Reginelli, Alfonso
Martinelli, Erika
author_facet Ciardiello, Davide
Del Tufo, Sara
Parente, Paola
Gravina, Antonietta Gerarda
Selvaggi, Francesco
Panarese, Iacopo
Franco, Renato
Caterino, Michele
Martini, Giulia
Ciardiello, Fortunato
Grassi, Roberto
Cappabianca, Salvatore
Reginelli, Alfonso
Martinelli, Erika
author_sort Ciardiello, Davide
collection PubMed
description Synchronous tumors of the rectum and anus are sporadic. Most cases in the literature are rectal adenocarcinomas with concomitant anal squamous cell carcinoma. To date, only two cases of concomitant squamous cell carcinomas of the rectum and anus are reported, and both were treated with up-front surgery and received abdominoperineal resection with colostomy. Here, we report the first case in the literature of a patient with synchronous HPV-positive squamous cell carcinoma of the rectum and anus treated with definitive chemoradiotherapy with curative intent. The clinical-radiological evaluation demonstrated complete tumor regression. After 2 years of follow-up, no evidence of recurrence was observed.
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spelling pubmed-102854952023-06-23 Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson Ciardiello, Davide Del Tufo, Sara Parente, Paola Gravina, Antonietta Gerarda Selvaggi, Francesco Panarese, Iacopo Franco, Renato Caterino, Michele Martini, Giulia Ciardiello, Fortunato Grassi, Roberto Cappabianca, Salvatore Reginelli, Alfonso Martinelli, Erika Front Oncol Oncology Synchronous tumors of the rectum and anus are sporadic. Most cases in the literature are rectal adenocarcinomas with concomitant anal squamous cell carcinoma. To date, only two cases of concomitant squamous cell carcinomas of the rectum and anus are reported, and both were treated with up-front surgery and received abdominoperineal resection with colostomy. Here, we report the first case in the literature of a patient with synchronous HPV-positive squamous cell carcinoma of the rectum and anus treated with definitive chemoradiotherapy with curative intent. The clinical-radiological evaluation demonstrated complete tumor regression. After 2 years of follow-up, no evidence of recurrence was observed. Frontiers Media S.A. 2023-06-08 /pmc/articles/PMC10285495/ /pubmed/37361596 http://dx.doi.org/10.3389/fonc.2023.1187623 Text en Copyright © 2023 Ciardiello, Del Tufo, Parente, Gravina, Selvaggi, Panarese, Franco, Caterino, Martini, Ciardiello, Grassi, Cappabianca, Reginelli and Martinelli https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ciardiello, Davide
Del Tufo, Sara
Parente, Paola
Gravina, Antonietta Gerarda
Selvaggi, Francesco
Panarese, Iacopo
Franco, Renato
Caterino, Michele
Martini, Giulia
Ciardiello, Fortunato
Grassi, Roberto
Cappabianca, Salvatore
Reginelli, Alfonso
Martinelli, Erika
Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson
title Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson
title_full Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson
title_fullStr Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson
title_full_unstemmed Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson
title_short Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson
title_sort case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285495/
https://www.ncbi.nlm.nih.gov/pubmed/37361596
http://dx.doi.org/10.3389/fonc.2023.1187623
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