Cargando…

The importance of mechanical conditions in the testing of excitation abnormalities in a population of electro-mechanical models of human ventricular cardiomyocytes

Background: Populations of in silico electrophysiological models of human cardiomyocytes represent natural variability in cell activity and are thoroughly calibrated and validated using experimental data from the human heart. The models have been shown to predict the effects of drugs and their pro-a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dokuchaev, Arsenii, Kursanov, Alexander, Balakina-Vikulova, Nathalie A., Katsnelson, Leonid B., Solovyova, Olga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285544/ https://www.ncbi.nlm.nih.gov/pubmed/37362439 http://dx.doi.org/10.3389/fphys.2023.1187956

Ejemplares similares

In silico analysis of the contribution of cardiomyocyte-fibroblast electromechanical interaction to the arrhythmia
por: Kursanov, Alexander, et al.
Publicado: (2023)

Mechano-calcium and mechano-electric feedbacks in the human cardiomyocyte analyzed in a mathematical model
por: Balakina-Vikulova, Nathalie A., et al.
Publicado: (2020)

The Effects of Mechanical Preload on Transmural Differences in Mechano-Calcium-Electric Feedback in Single Cardiomyocytes: Experiments and Mathematical Models
por: Khokhlova, Anastasia, et al.
Publicado: (2020)

Combination of personalized computational modeling and machine learning for optimization of left ventricular pacing site in cardiac resynchronization therapy
por: Dokuchaev, Arsenii, et al.
Publicado: (2023)

Unsupervised deep network for image texture transformation: Improving the quality of cross-correlation analysis and mechanical vortex visualisation during cardiac fibrillation
por: Mangileva, Daria, et al.
Publicado: (2023)

Machine Learning Prediction of Cardiac Resynchronisation Therapy Response From Combination of Clinical and Model-Driven Data
por: Khamzin, Svyatoslav, et al.
Publicado: (2021)

Editorial: Mechano-Calcium, Mechano-Electric, and Mechano-Metabolic Feedback Loops: Contribution to the Myocardial Contraction in Health and Diseases
por: Peyronnet, Rémi, et al.
Publicado: (2021)

The cardiac muscle duplex as a method to study myocardial heterogeneity
por: Solovyova, O., et al.
Publicado: (2014)

Gaussian Process Regressions for Inverse Problems and Parameter Searches in Models of Ventricular Mechanics
por: Di Achille, Paolo, et al.
Publicado: (2018)

Three-Week-Old Rabbit Ventricular Cardiomyocytes as a Novel System to Study Cardiac Excitation and EC Coupling
por: Kabakov, Anatoli Y., et al.
Publicado: (2021)

Corrigendum: Three-week-old rabbit ventricular cardiomyocytes as a novel system to study cardiac excitation and EC coupling
por: Kabakov, Anatoli Y., et al.
Publicado: (2023)

Redox mechanisms of cardiomyocyte mitochondrial protection
por: Bartz, Raquel R., et al.
Publicado: (2015)

In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes
por: Zhou, Xin, et al.
Publicado: (2016)

Optogenetic Hyperpolarization of Cardiomyocytes Terminates Ventricular Arrhythmia
por: Funken, Maximilian, et al.
Publicado: (2019)

A Numerical Study of Scalable Cardiac Electro-Mechanical Solvers on HPC Architectures
por: Colli Franzone, Piero, et al.
Publicado: (2018)

The Electrogenic Na(+)/K(+) Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study
por: Britton, Oliver J., et al.
Publicado: (2017)

A Novel In Silico Electromechanical Model of Human Ventricular Cardiomyocyte
por: Bartolucci, Chiara, et al.
Publicado: (2022)

Corrigendum: The Electrogenic Na(+)/K(+) Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study
por: Britton, Oliver J., et al.
Publicado: (2017)

Distinguishing between overdrive excited and suppressed ventricular beats in guinea pig ventricular myocardium
por: Greer-Short, Amara, et al.
Publicado: (2015)

A Fully-Coupled Electro-Mechanical Whole-Heart Computational Model: Influence of Cardiac Contraction on the ECG
por: Moss, Robin, et al.
Publicado: (2021)

Pathophysiological Mechanisms of Premature Ventricular Complexes
por: Hoogendijk, Mark G., et al.
Publicado: (2020)

Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: Mechanisms and Potential Therapeutic Implications
por: Chen, Gong, et al.
Publicado: (2018)

The Role of Membrane Capacitance in Cardiac Impulse Conduction: An Optogenetic Study With Non-excitable Cells Coupled to Cardiomyocytes
por: De Simone, Stefano Andrea, et al.
Publicado: (2020)

Human Cardiomyocyte Progenitor Cells in Co-culture with Rat Cardiomyocytes Form a Pro-arrhythmic Substrate: Evidence for Two Different Arrhythmogenic Mechanisms
por: Smit, Nicoline W., et al.
Publicado: (2017)

The Acute Effects of Leptin on the Contractility of Isolated Rat Atrial and Ventricular Cardiomyocytes
por: Khokhlova, Anastasia, et al.
Publicado: (2022)

Computational models of ventricular mechanics and adaptation in response to right-ventricular pressure overload
por: Odeigah, Oscar O., et al.
Publicado: (2022)

Slow Recovery of Excitability Increases Ventricular Fibrillation Risk as Identified by Emulation
por: Lawson, Brodie A., et al.
Publicado: (2018)

Excitation and injury of adult ventricular cardiomyocytes by nano- to millisecond electric shocks
por: Semenov, Iurii, et al.
Publicado: (2018)

The Antiarrhythmic Mechanisms of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia
por: Li, Yukun, et al.
Publicado: (2022)

Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities
por: Paci, Michelangelo, et al.
Publicado: (2018)

Calcitriol, the Bioactive Metabolite of Vitamin D, Increases Ventricular K(+) Currents in Isolated Mouse Cardiomyocytes
por: Tamayo, María, et al.
Publicado: (2018)

A multiscale chemo-electro-mechanical skeletal muscle model to analyze muscle contraction and force generation for different muscle fiber arrangements
por: Heidlauf, Thomas, et al.
Publicado: (2014)

Electro-mechanical ventricular capture with peripheral lithotripsy, the plots thicken
por: Aljundi, Saif, et al.
Publicado: (2023)

Model order reduction for left ventricular mechanics via congruency training
por: Di Achille, Paolo, et al.
Publicado: (2020)

Abnormal Calcium Handling in Duchenne Muscular Dystrophy: Mechanisms and Potential Therapies
por: Mareedu, Satvik, et al.
Publicado: (2021)

Research Progress on the Mechanism Between Polycystic Ovary Syndrome and Abnormal Endometrium
por: Xue, Zhu, et al.
Publicado: (2021)

The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeat
por: Capel, Rebecca A., et al.
Publicado: (2015)

The Importance of Mechanical Forces for in vitro Endothelial Cell Biology
por: Gordon, Emma, et al.
Publicado: (2020)

A Distinct Pool of Na(v)1.5 Channels at the Lateral Membrane of Murine Ventricular Cardiomyocytes
por: Rougier, Jean-Sébastien, et al.
Publicado: (2019)

Length-Dependent Activation of Contractility and Ca-Transient Kinetics in Auxotonically Contracting Isolated Rat Ventricular Cardiomyocytes
por: Lookin, Oleg, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_qamsp8qgfkpkjv5p3ck2opicvs