Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling

Congenital heart defects (CHDs) are frequent in children with Down syndrome (DS), caused by trisomy of chromosome 21. However, the underlying mechanisms are poorly understood. Here, using a human-induced pluripotent stem cell (iPSC)-based model and the Dp(16)1Yey/+ (Dp16) mouse model of DS, we ident...

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Detalles Bibliográficos
Autores principales: Chi, Congwu, Knight, Walter E., Riching, Andrew S., Zhang, Zhen, Tatavosian, Roubina, Zhuang, Yonghua, Moldovan, Radu, Rachubinski, Angela L., Gao, Dexiang, Xu, Hongyan, Espinosa, Joaquin M., Song, Kunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285545/
https://www.ncbi.nlm.nih.gov/pubmed/37360690
http://dx.doi.org/10.1016/j.isci.2023.107012

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