Using a Clinically Interpretable End Point Composed of Multiple Outcomes to Evaluate Totality of Treatment Effect in Comparative Oncology Studies

This cohort study demonstrates how to use cumulative event count curves to create a clinically meaningful end point by simultaneously considering recurrence, progression, and survival times from the individual patient.

Detalles Bibliográficos
Autores principales: Wang, Xiaofei, McCaw, Zachary R., Tian, Lu, Stinchcombe, Thomas E., Vokes, Everett, Ludmir, Ethan B., Wei, Lee-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2023
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285578/
https://www.ncbi.nlm.nih.gov/pubmed/37342044
http://dx.doi.org/10.1001/jamanetworkopen.2023.19055
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author Wang, Xiaofei
McCaw, Zachary R.
Tian, Lu
Stinchcombe, Thomas E.
Vokes, Everett
Ludmir, Ethan B.
Wei, Lee-Jen
author_facet Wang, Xiaofei
McCaw, Zachary R.
Tian, Lu
Stinchcombe, Thomas E.
Vokes, Everett
Ludmir, Ethan B.
Wei, Lee-Jen
author_sort Wang, Xiaofei
collection PubMed
description This cohort study demonstrates how to use cumulative event count curves to create a clinically meaningful end point by simultaneously considering recurrence, progression, and survival times from the individual patient.
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spelling pubmed-102855782023-06-23 Using a Clinically Interpretable End Point Composed of Multiple Outcomes to Evaluate Totality of Treatment Effect in Comparative Oncology Studies Wang, Xiaofei McCaw, Zachary R. Tian, Lu Stinchcombe, Thomas E. Vokes, Everett Ludmir, Ethan B. Wei, Lee-Jen JAMA Netw Open Research Letter This cohort study demonstrates how to use cumulative event count curves to create a clinically meaningful end point by simultaneously considering recurrence, progression, and survival times from the individual patient. American Medical Association 2023-06-21 /pmc/articles/PMC10285578/ /pubmed/37342044 http://dx.doi.org/10.1001/jamanetworkopen.2023.19055 Text en Copyright 2023 Wang X et al. JAMA Network Open. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the CC-BY License.
spellingShingle Research Letter
Wang, Xiaofei
McCaw, Zachary R.
Tian, Lu
Stinchcombe, Thomas E.
Vokes, Everett
Ludmir, Ethan B.
Wei, Lee-Jen
Using a Clinically Interpretable End Point Composed of Multiple Outcomes to Evaluate Totality of Treatment Effect in Comparative Oncology Studies
title Using a Clinically Interpretable End Point Composed of Multiple Outcomes to Evaluate Totality of Treatment Effect in Comparative Oncology Studies
title_full Using a Clinically Interpretable End Point Composed of Multiple Outcomes to Evaluate Totality of Treatment Effect in Comparative Oncology Studies
title_fullStr Using a Clinically Interpretable End Point Composed of Multiple Outcomes to Evaluate Totality of Treatment Effect in Comparative Oncology Studies
title_full_unstemmed Using a Clinically Interpretable End Point Composed of Multiple Outcomes to Evaluate Totality of Treatment Effect in Comparative Oncology Studies
title_short Using a Clinically Interpretable End Point Composed of Multiple Outcomes to Evaluate Totality of Treatment Effect in Comparative Oncology Studies
title_sort using a clinically interpretable end point composed of multiple outcomes to evaluate totality of treatment effect in comparative oncology studies
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285578/
https://www.ncbi.nlm.nih.gov/pubmed/37342044
http://dx.doi.org/10.1001/jamanetworkopen.2023.19055
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