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Synthesis and biological evaluation of novel β-lactam-metallo β-lactamase inhibitors

β-lactamases are enzymes that deactivate β-lactam antibiotics through a hydrolysis mechanism. There are two known types of β-lactamases: serine β-lactamases (SBLs) and metallo β-lactamases (MBLs). The two existing strategies to overcome β-lactamase-mediated resistance are (a) to develop novel β-lact...

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Detalles Bibliográficos
Autores principales:	Shungube, Mbongeni, Hlophe, Ayanda K., Girdhari, Letisha, Sabe, Victor T., Peters, Byron B., Reddy, Nakita, Omolabi, Kehinde F., Chetty, Lloyd, Arumugam, Thilona, Chuturgoon, Anil, Kruger, Hendrik G., Arvidsson, Per I., Qin, Hua-Li, Naicker, Tricia, Govender, Thavendran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285615/ https://www.ncbi.nlm.nih.gov/pubmed/37362332 http://dx.doi.org/10.1039/d3ra02490c

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