What the BTBR/J mouse has taught us about diabetes and diabetic complications

Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a...

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Autores principales: Keller, Mark P., Hudkins, Kelly L., Shalev, Anath, Bhatnagar, Sushant, Kebede, Melkam A., Merrins, Matthew J., Davis, Dawn Belt, Alpers, Charles E., Kimple, Michelle E., Attie, Alan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285641/
https://www.ncbi.nlm.nih.gov/pubmed/37360692
http://dx.doi.org/10.1016/j.isci.2023.107036
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author Keller, Mark P.
Hudkins, Kelly L.
Shalev, Anath
Bhatnagar, Sushant
Kebede, Melkam A.
Merrins, Matthew J.
Davis, Dawn Belt
Alpers, Charles E.
Kimple, Michelle E.
Attie, Alan D.
author_facet Keller, Mark P.
Hudkins, Kelly L.
Shalev, Anath
Bhatnagar, Sushant
Kebede, Melkam A.
Merrins, Matthew J.
Davis, Dawn Belt
Alpers, Charles E.
Kimple, Michelle E.
Attie, Alan D.
author_sort Keller, Mark P.
collection PubMed
description Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the Lep(ob) mutation. We went on to discover that the BTBR-Lep(ob) mouse is an excellent model of diabetic nephropathy and is now widely used by nephrologists in academia and the pharmaceutical industry. In this review, we describe the motivation for developing this animal model, the many genes identified and the insights about diabetes and diabetes complications derived from >100 studies conducted in this remarkable animal model.
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spelling pubmed-102856412023-06-23 What the BTBR/J mouse has taught us about diabetes and diabetic complications Keller, Mark P. Hudkins, Kelly L. Shalev, Anath Bhatnagar, Sushant Kebede, Melkam A. Merrins, Matthew J. Davis, Dawn Belt Alpers, Charles E. Kimple, Michelle E. Attie, Alan D. iScience Review Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the Lep(ob) mutation. We went on to discover that the BTBR-Lep(ob) mouse is an excellent model of diabetic nephropathy and is now widely used by nephrologists in academia and the pharmaceutical industry. In this review, we describe the motivation for developing this animal model, the many genes identified and the insights about diabetes and diabetes complications derived from >100 studies conducted in this remarkable animal model. Elsevier 2023-06-07 /pmc/articles/PMC10285641/ /pubmed/37360692 http://dx.doi.org/10.1016/j.isci.2023.107036 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Keller, Mark P.
Hudkins, Kelly L.
Shalev, Anath
Bhatnagar, Sushant
Kebede, Melkam A.
Merrins, Matthew J.
Davis, Dawn Belt
Alpers, Charles E.
Kimple, Michelle E.
Attie, Alan D.
What the BTBR/J mouse has taught us about diabetes and diabetic complications
title What the BTBR/J mouse has taught us about diabetes and diabetic complications
title_full What the BTBR/J mouse has taught us about diabetes and diabetic complications
title_fullStr What the BTBR/J mouse has taught us about diabetes and diabetic complications
title_full_unstemmed What the BTBR/J mouse has taught us about diabetes and diabetic complications
title_short What the BTBR/J mouse has taught us about diabetes and diabetic complications
title_sort what the btbr/j mouse has taught us about diabetes and diabetic complications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285641/
https://www.ncbi.nlm.nih.gov/pubmed/37360692
http://dx.doi.org/10.1016/j.isci.2023.107036
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