Metformin alleviates lung-endothelial hyperpermeability by regulating cofilin-1/PP2AC pathway

Background: Microvascular endothelial hyperpermeability is an earliest pathological hallmark in Acute Lung Injury (ALI), which progressively leads to Acute Respiratory Distress Syndrome (ARDS). Recently, vascular protective and anti-inflammatory effect of metformin, irrespective of glycemic control,...

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Detalles Bibliográficos
Autores principales: Siddiqui, M. Rizwan, Reddy, Narsa M., Faridi, Hafeez M., Shahid, Mohd, Shanley, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285707/
https://www.ncbi.nlm.nih.gov/pubmed/37361221
http://dx.doi.org/10.3389/fphar.2023.1211460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285707/
https://www.ncbi.nlm.nih.gov/pubmed/37361221
http://dx.doi.org/10.3389/fphar.2023.1211460

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