Cargando…

Metformin alleviates lung-endothelial hyperpermeability by regulating cofilin-1/PP2AC pathway

Background: Microvascular endothelial hyperpermeability is an earliest pathological hallmark in Acute Lung Injury (ALI), which progressively leads to Acute Respiratory Distress Syndrome (ARDS). Recently, vascular protective and anti-inflammatory effect of metformin, irrespective of glycemic control,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siddiqui, M. Rizwan, Reddy, Narsa M., Faridi, Hafeez M., Shahid, Mohd, Shanley, Thomas P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285707/ https://www.ncbi.nlm.nih.gov/pubmed/37361221 http://dx.doi.org/10.3389/fphar.2023.1211460

Ejemplares similares

AKT/PACS2 Participates in Renal Vascular Hyperpermeability by Regulating Endothelial Fatty Acid Oxidation in Diabetic Mice
por: Shu, Zhihao, et al.
Publicado: (2022)

Bivalirudin Attenuates Thrombin-Induced Endothelial Hyperpermeability via S1P/S1PR2 Category: Original Articles
por: Ye, Haowen, et al.
Publicado: (2021)

Gas6 Attenuates Sepsis-Induced Tight Junction Injury and Vascular Endothelial Hyperpermeability via the Axl/NF-κB Signaling Pathway
por: Ni, Jingjing, et al.
Publicado: (2019)

Endothelial mechanisms for inactivation of inflammation-induced hyperpermeability
por: Nepali, Prerna R., et al.
Publicado: (2023)

Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability
por: Hu, Tao, et al.
Publicado: (2020)

Inhibition of p38 MAPK Mitigates Lung Ischemia Reperfusion Injury by Reducing Blood–Air Barrier Hyperpermeability
por: Wang, Tiantian, et al.
Publicado: (2020)

Metformin Alleviates LPS-Induced Acute Lung Injury by Regulating the SIRT1/NF-κB/NLRP3 Pathway and Inhibiting Endothelial Cell Pyroptosis
por: Zhang, Yunqian, et al.
Publicado: (2022)

Emerging Potential of Immediate Early Response Gene X‐1 in Cardiovascular and Metabolic Diseases
por: Shahid, Mohd, et al.
Publicado: (2018)

Simvastatin Alleviates Hyperpermeability of Glomerular Endothelial Cells in Early-Stage Diabetic Nephropathy by Inhibition of RhoA/ROCK1
por: Peng, Hui, et al.
Publicado: (2013)

Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability
por: Li, Yicong, et al.
Publicado: (2016)

Effect of Lipoxin A(4) on Lipopolysaccharide-Induced Endothelial Hyperpermeability
por: Pang, Huayan, et al.
Publicado: (2011)

Mechanisms of Mechanical Force Induced Pulmonary Vascular Endothelial Hyperpermeability
por: Lai, Yan, et al.
Publicado: (2021)

In vitro endothelial hyperpermeability occurs early following traumatic hemorrhagic shock
por: van Leeuwen, Anoek L.I., et al.
Publicado: (2020)

Metformin Alleviates Steatohepatitis in Diet-Induced Obese Mice in a SIRT1-Dependent Way
por: Guo, Wan-rong, et al.
Publicado: (2021)

Inflammatory Immune Cytokine TNF-α Modulates Ezrin Protein Activation via FAK/RhoA Signaling Pathway in PMVECs Hyperpermeability
por: Zhou, Qun, et al.
Publicado: (2021)

Deubiquitinase Inhibitors Impair Leukemic Cell Migration Through Cofilin Oxidation and Alteration of Actin Reorganization
por: Larbret, Frédéric, et al.
Publicado: (2022)

Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability
por: Puerta-Guardo, Henry, et al.
Publicado: (2016)

Malaysian Tualang Honey Inhibits Hydrogen Peroxide-Induced Endothelial Hyperpermeability
por: Devasvaran, Kogilavanee, et al.
Publicado: (2019)

Somatostatin Primes Endothelial Cells for Agonist-Induced Hyperpermeability and Angiogenesis In Vitro
por: Aslam, Muhammad, et al.
Publicado: (2022)

Tea polyphenols alleviate high fat and high glucose-induced endothelial hyperpermeability by attenuating ROS production via NADPH oxidase pathway
por: Zuo, Xuezhi, et al.
Publicado: (2014)

CXCL13 Is Involved in the Lipopolysaccharide-Induced Hyperpermeability of Umbilical Vein Endothelial Cells
por: Chen, Wen, et al.
Publicado: (2020)

Retraction Note: Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability
por: Li, Yicong, et al.
Publicado: (2019)

Vascular permeability, vascular hyperpermeability and angiogenesis
por: Nagy, Janice A., et al.
Publicado: (2008)

Anti-inflammatory Mechanism of Geniposide: Inhibiting the Hyperpermeability of Fibroblast-Like Synoviocytes via the RhoA/p38MAPK/NF-κB/F-Actin Signal Pathway
por: Deng, Ran, et al.
Publicado: (2018)

Genipin alleviates vascular hyperpermeability following hemorrhagic shock by up-regulation of SIRT3/autophagy
por: Shumin, Cai, et al.
Publicado: (2018)

Metformin Alleviates Endometriosis and Potentiates Endometrial Receptivity via Decreasing VEGF and MMP9 and Increasing Leukemia Inhibitor Factor and HOXA10
por: Cheng, Jing, et al.
Publicado: (2022)

Deficiency of endothelial FGFR1 alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice
por: Long, Yanrong, et al.
Publicado: (2022)

Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo
por: Ashina, Kohei, et al.
Publicado: (2015)

Anesthetic Propofol Overdose Causes Vascular Hyperpermeability by Reducing Endothelial Glycocalyx and ATP Production
por: Lin, Ming-Chung, et al.
Publicado: (2015)

Role of vasodilator-stimulated phosphoprotein in human cytomegalovirus-induced hyperpermeability of human endothelial cells
por: Tian, Yihao, et al.
Publicado: (2018)

Metformin Ameliorates Gestational Diabetes Mellitus-Induced Endothelial Dysfunction via Downregulation of p65 and Upregulation of Nrf2
por: Sun, Cong Cong, et al.
Publicado: (2020)

Cigarette smoke extract exacerbates hyperpermeability of cerebral endothelial cells after oxygen glucose deprivation and reoxygenation
por: Bernard, Ashton, et al.
Publicado: (2019)

Development and Evaluation of Novel Metformin Derivative Metformin Threonate for Brain Ischemia Treatment
por: Zhang, Gufang, et al.
Publicado: (2022)

Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage
por: Ramadan, Raghda, et al.
Publicado: (2020)

Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway
por: Han, Xiqiong, et al.
Publicado: (2018)

IL-4 Causes Hyperpermeability of Vascular Endothelial Cells through Wnt5A Signaling
por: Skaria, Tom, et al.
Publicado: (2016)

Pressure-dependent NOS activation contributes to endothelial hyperpermeability in a model of acute heart failure
por: Chignalia, Andreia Z., et al.
Publicado: (2018)

RAGE Plays a Role in LPS-Induced NF-κB Activation and Endothelial Hyperpermeability
por: Wang, Liqun, et al.
Publicado: (2017)

Tissue Kallikrein Exacerbating Sepsis-Induced Endothelial Hyperpermeability is Highly Predictive of Severity and Mortality in Sepsis
por: Ran, Xiao, et al.
Publicado: (2021)

Oxidized High-Density Lipoprotein Induces Endothelial Fibrosis Promoting Hyperpermeability, Hypotension, and Increased Mortality
por: Rojas, Macarena, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8r84s1qclsto71qmv59rcamfro