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The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease involving mainly the colorectal mucosa and submucosa, the incidence of which has been on the rise in recent years. Nuclear factor erythroid 2-related factor 2 (Nrf2), known for its key function as a transcription factor, is pivotal in i...

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Autores principales: Peng, Shuai, Shen, Lei, Yu, Xiaoyun, Zhang, Li, Xu, Ke, Xia, Yuan, Zha, Lanlan, Wu, Jing, Luo, Hesheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285877/
https://www.ncbi.nlm.nih.gov/pubmed/37359553
http://dx.doi.org/10.3389/fimmu.2023.1200111
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author Peng, Shuai
Shen, Lei
Yu, Xiaoyun
Zhang, Li
Xu, Ke
Xia, Yuan
Zha, Lanlan
Wu, Jing
Luo, Hesheng
author_facet Peng, Shuai
Shen, Lei
Yu, Xiaoyun
Zhang, Li
Xu, Ke
Xia, Yuan
Zha, Lanlan
Wu, Jing
Luo, Hesheng
author_sort Peng, Shuai
collection PubMed
description Ulcerative colitis (UC) is a chronic inflammatory bowel disease involving mainly the colorectal mucosa and submucosa, the incidence of which has been on the rise in recent years. Nuclear factor erythroid 2-related factor 2 (Nrf2), known for its key function as a transcription factor, is pivotal in inducing antioxidant stress and regulating inflammatory responses. Numerous investigations have demonstrated the involvement of the Nrf2 pathway in maintaining the development and normal function of the intestine, the development of UC, and UC-related intestinal fibrosis and carcinogenesis; meanwhile, therapeutic agents targeting the Nrf2 pathway have been widely investigated. This paper reviews the research progress of the Nrf2 signaling pathway in UC.
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spelling pubmed-102858772023-06-23 The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis Peng, Shuai Shen, Lei Yu, Xiaoyun Zhang, Li Xu, Ke Xia, Yuan Zha, Lanlan Wu, Jing Luo, Hesheng Front Immunol Immunology Ulcerative colitis (UC) is a chronic inflammatory bowel disease involving mainly the colorectal mucosa and submucosa, the incidence of which has been on the rise in recent years. Nuclear factor erythroid 2-related factor 2 (Nrf2), known for its key function as a transcription factor, is pivotal in inducing antioxidant stress and regulating inflammatory responses. Numerous investigations have demonstrated the involvement of the Nrf2 pathway in maintaining the development and normal function of the intestine, the development of UC, and UC-related intestinal fibrosis and carcinogenesis; meanwhile, therapeutic agents targeting the Nrf2 pathway have been widely investigated. This paper reviews the research progress of the Nrf2 signaling pathway in UC. Frontiers Media S.A. 2023-06-05 /pmc/articles/PMC10285877/ /pubmed/37359553 http://dx.doi.org/10.3389/fimmu.2023.1200111 Text en Copyright © 2023 Peng, Shen, Yu, Zhang, Xu, Xia, Zha, Wu and Luo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Peng, Shuai
Shen, Lei
Yu, Xiaoyun
Zhang, Li
Xu, Ke
Xia, Yuan
Zha, Lanlan
Wu, Jing
Luo, Hesheng
The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis
title The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis
title_full The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis
title_fullStr The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis
title_full_unstemmed The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis
title_short The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis
title_sort role of nrf2 in the pathogenesis and treatment of ulcerative colitis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10285877/
https://www.ncbi.nlm.nih.gov/pubmed/37359553
http://dx.doi.org/10.3389/fimmu.2023.1200111
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